Protection from chemotherapy-induced alopecia in a rat model

Atif M. Hussein, Joaquin J. Jimenez, Catherine A. Mccall, Adel A. Yunis

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Alopecia (hair loss) is among the most distressing side effects of cancer chemotherapy. Little progress has been made, however, in its prevention or treatment, partly because of the tack of suitable experimental model. In recent work on the treatment of myelogenous leukemia in the rat, the following observations were made: (i) treatment of 8-day-old rats with cytosine arabinoside consistently produced alopecia, and (ii) ImuVert, a biologic response modifier derived from the bacterium Serratia marcescens, uniformly produced complete protection against the alopecia. In subsequent experiments, both cyclophosphamide and doxorubicin also produced alopecia in this model, and the doxorubicin-induced alopecia was prevented by treatment with ImuVert. The potential relevance of these observations to chemotherapy-induced alopecia in the clinical setting should be examined.

Original languageEnglish (US)
Pages (from-to)1564-1566
Number of pages3
JournalScience
Volume249
Issue number4976
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Protection from chemotherapy-induced alopecia in a rat model'. Together they form a unique fingerprint.

  • Cite this