Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D

Joaquin J Jimenez, Adel A Yunis

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 μg of topical 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 μg protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.

Original languageEnglish
Pages (from-to)5123-5125
Number of pages3
JournalCancer Research
Volume52
Issue number18
StatePublished - Sep 15 1992

Fingerprint

Alopecia
Cyclophosphamide
Calcitriol
Drug Therapy
Cytarabine
Etoposide
Secosteroids
Biological Factors
Doxorubicin
Appointments and Schedules
1,25-dihydroxyvitamin D

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D. / Jimenez, Joaquin J; Yunis, Adel A.

In: Cancer Research, Vol. 52, No. 18, 15.09.1992, p. 5123-5125.

Research output: Contribution to journalArticle

@article{6d741b33e1644936a67ff27066f7e980,
title = "Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D",
abstract = "We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 μg of topical 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 μg protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.",
author = "Jimenez, {Joaquin J} and Yunis, {Adel A}",
year = "1992",
month = "9",
day = "15",
language = "English",
volume = "52",
pages = "5123--5125",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "18",

}

TY - JOUR

T1 - Protection from chemotherapy-induced alopecia by 1,25-dihydroxyvitamin D

AU - Jimenez, Joaquin J

AU - Yunis, Adel A

PY - 1992/9/15

Y1 - 1992/9/15

N2 - We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 μg of topical 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 μg protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.

AB - We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 μg of topical 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 μg protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.

UR - http://www.scopus.com/inward/record.url?scp=0026793916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026793916&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 5123

EP - 5125

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 18

ER -