Protection from Chemotherapy-induced Alopecia by 1,25-Dihydroxyvitamin D3

Joaquin J. Jimenez, Adel A. Yunis

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to protect from chemotherapy-induced alopecia. In three separate experiments, 0.2 μg of topical 1,25-dihydroxyvitamin D3 protected rats from alopecia induced by etoposide, cytoxan, and an Adriamycin-cytoxan combination. In another experiment, 0.1 μg protected rats from etoposide-induced alopecia at the site of application. 1,25-Dihydroxyvitamin D3 may offer a new and exciting approach to the prevention of chemotherapy-induced alopecia.

Original languageEnglish (US)
Pages (from-to)5123-5125
Number of pages3
JournalCancer Research
Volume52
Issue number18
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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