Protection against murine cerebral malaria by dietary-induced oxidative stress

O. A. Levander, R. Fontela, V. C. Morris, Arba L Ager

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Feeding 20% (w/w) menhaden-fish oil in a standard laboratory chow diet for 4 wk partially protected CBA/CaJ mice from the central nervous system consequences of infection with Plasmodium berghei (ANKA). Full protection (complete survival for 14 days postinfection) could be obtained by feeding a purified pro-oxidant vitamin E-deficient diet containing 4% (w/w) menhaden oil (MO - VE diet). The purified pro-oxidant MO - VE diet also exerted a pronounced suppressive effect against the parasite (depressed 6-day parasitemias). The antimalarial effect of the MO - VE diet could be prevented by supplementing the diet with vitamin E or with either of 2 synthetic antioxidants, N,N'-diphenyl-p-phenylenediamine or probucol. These results suggest that the fish oil exerts its antimalarial effect by imposing a dietary-induced oxidative stress on the infected host erythrocyte, the parasite, or both. Nutritional manipulation of host oxidative stress status may be a useful adjunct therapy in patients undergoing treatment with pro- oxidant antimalarials such as drugs of the qinghaosu family.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalJournal of Parasitology
Volume81
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Cerebral Malaria
malaria
Oxidative Stress
oxidative stress
diet
Diet
antimalarials
mice
Antimalarials
oxidants
oxidant
menhaden oil
Reactive Oxygen Species
Fish Oils
vitamin
Vitamin E
fish oils
vitamin E
oil
parasite

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Parasitology
  • Microbiology

Cite this

Protection against murine cerebral malaria by dietary-induced oxidative stress. / Levander, O. A.; Fontela, R.; Morris, V. C.; Ager, Arba L.

In: Journal of Parasitology, Vol. 81, No. 1, 1995, p. 99-103.

Research output: Contribution to journalArticle

Levander, OA, Fontela, R, Morris, VC & Ager, AL 1995, 'Protection against murine cerebral malaria by dietary-induced oxidative stress', Journal of Parasitology, vol. 81, no. 1, pp. 99-103. https://doi.org/10.2307/3284013
Levander, O. A. ; Fontela, R. ; Morris, V. C. ; Ager, Arba L. / Protection against murine cerebral malaria by dietary-induced oxidative stress. In: Journal of Parasitology. 1995 ; Vol. 81, No. 1. pp. 99-103.
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