Abstract
Feeding 20% (w/w) menhaden-fish oil in a standard laboratory chow diet for 4 wk partially protected CBA/CaJ mice from the central nervous system consequences of infection with Plasmodium berghei (ANKA). Full protection (complete survival for 14 days postinfection) could be obtained by feeding a purified pro-oxidant vitamin E-deficient diet containing 4% (w/w) menhaden oil (MO - VE diet). The purified pro-oxidant MO - VE diet also exerted a pronounced suppressive effect against the parasite (depressed 6-day parasitemias). The antimalarial effect of the MO - VE diet could be prevented by supplementing the diet with vitamin E or with either of 2 synthetic antioxidants, N,N'-diphenyl-p-phenylenediamine or probucol. These results suggest that the fish oil exerts its antimalarial effect by imposing a dietary-induced oxidative stress on the infected host erythrocyte, the parasite, or both. Nutritional manipulation of host oxidative stress status may be a useful adjunct therapy in patients undergoing treatment with pro- oxidant antimalarials such as drugs of the qinghaosu family.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 99-103 |
| Number of pages | 5 |
| Journal | Journal of Parasitology |
| Volume | 81 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Parasitology
- Microbiology
Cite this
Protection against murine cerebral malaria by dietary-induced oxidative stress. / Levander, O. A.; Fontela, R.; Morris, V. C.; Ager, Arba L.
In: Journal of Parasitology, Vol. 81, No. 1, 1995, p. 99-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protection against murine cerebral malaria by dietary-induced oxidative stress
AU - Levander, O. A.
AU - Fontela, R.
AU - Morris, V. C.
AU - Ager, Arba L
PY - 1995
Y1 - 1995
N2 - Feeding 20% (w/w) menhaden-fish oil in a standard laboratory chow diet for 4 wk partially protected CBA/CaJ mice from the central nervous system consequences of infection with Plasmodium berghei (ANKA). Full protection (complete survival for 14 days postinfection) could be obtained by feeding a purified pro-oxidant vitamin E-deficient diet containing 4% (w/w) menhaden oil (MO - VE diet). The purified pro-oxidant MO - VE diet also exerted a pronounced suppressive effect against the parasite (depressed 6-day parasitemias). The antimalarial effect of the MO - VE diet could be prevented by supplementing the diet with vitamin E or with either of 2 synthetic antioxidants, N,N'-diphenyl-p-phenylenediamine or probucol. These results suggest that the fish oil exerts its antimalarial effect by imposing a dietary-induced oxidative stress on the infected host erythrocyte, the parasite, or both. Nutritional manipulation of host oxidative stress status may be a useful adjunct therapy in patients undergoing treatment with pro- oxidant antimalarials such as drugs of the qinghaosu family.
AB - Feeding 20% (w/w) menhaden-fish oil in a standard laboratory chow diet for 4 wk partially protected CBA/CaJ mice from the central nervous system consequences of infection with Plasmodium berghei (ANKA). Full protection (complete survival for 14 days postinfection) could be obtained by feeding a purified pro-oxidant vitamin E-deficient diet containing 4% (w/w) menhaden oil (MO - VE diet). The purified pro-oxidant MO - VE diet also exerted a pronounced suppressive effect against the parasite (depressed 6-day parasitemias). The antimalarial effect of the MO - VE diet could be prevented by supplementing the diet with vitamin E or with either of 2 synthetic antioxidants, N,N'-diphenyl-p-phenylenediamine or probucol. These results suggest that the fish oil exerts its antimalarial effect by imposing a dietary-induced oxidative stress on the infected host erythrocyte, the parasite, or both. Nutritional manipulation of host oxidative stress status may be a useful adjunct therapy in patients undergoing treatment with pro- oxidant antimalarials such as drugs of the qinghaosu family.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028955093&partnerID=8YFLogxK
U2 - 10.2307/3284013
DO - 10.2307/3284013
M3 - Article
C2 - 7876987
AN - SCOPUS:0028955093
VL - 81
SP - 99
EP - 103
JO - Journal of Parasitology
JF - Journal of Parasitology
SN - 0022-3395
IS - 1
ER -