Protection against chemotherapy-induced alopecia: Targeting ATP-binding cassette transporters in the hair follicle?

Iain S. Haslam, Aaron Pitre, John D. Schuetz, Ralf Paus

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Currently, efficacious treatments for chemotherapy-induced alopecia (hair loss) are lacking, and incidences of permanent hair loss following high-dose chemotherapy are on the increase. In this article, we describe mechanisms by which the pharmacological defense status of the hair follicle might be enhanced, thereby reducing the accumulation of cytotoxic cancer drugs and preventing or reducing hair loss and damage. We believe this could be achieved via the selective increase in ATP-binding cassette (ABC) transporter expression within the hair follicle epithelium, following application of topical agonists for regulatory nuclear receptors. Clinical application would require the development of hair follicle-targeted formulations, potentially utilizing nanoparticle technology. This novel approach has the potential to yield entirely new therapeutic options for the treatment and management of chemotherapy-induced alopecia, providing significant psychological and physical benefit to cancer patients.

Original languageEnglish (US)
Pages (from-to)599-604
Number of pages6
JournalTrends in Pharmacological Sciences
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

Fingerprint

ATP-Binding Cassette Transporters
Chemotherapy
Hair Follicle
Alopecia
Drug Therapy
Cytoplasmic and Nuclear Receptors
Nanoparticles
Neoplasms
Pharmaceutical Preparations
Therapeutics
Epithelium
Pharmacology
Psychology
Technology
Incidence

Keywords

  • ATP-dependent transporters and drug resistance
  • nuclear receptors
  • structure and function of ABC transporters
  • xenobiotic defense

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Protection against chemotherapy-induced alopecia : Targeting ATP-binding cassette transporters in the hair follicle? / Haslam, Iain S.; Pitre, Aaron; Schuetz, John D.; Paus, Ralf.

In: Trends in Pharmacological Sciences, Vol. 34, No. 11, 01.11.2013, p. 599-604.

Research output: Contribution to journalArticle

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