Protecting pancreatic β-cells

Antonello Pileggi, Elizabeth S. Fenjves, Dagmar Klein, Camillo Ricordi, Ricardo L. Pastori

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Type 1 diabetes mellitus is an autoimmune disorder in which the insulin-producing β-cells of the pancreatic islets of Langerhans are selectively destroyed. Transplantation of allogeneic islets offers a novel therapeutic approach for type 1 diabetic patients. Primary obstacles to the successful outcome of this treatment are loss of the islets occurring first during the isolation procedure and then immediately following transplantation. The genetic make up of β-cells contributes to making them particularly vulnerable to apoptosis and necrosis-induced cell death caused by the trauma of the isolation procedure and by non-specific inflammatory events at the transplantation site. In this review we present description of chemical and molecular biology based strategies to confer cytoprotection to β-cells.

Original languageEnglish (US)
Pages (from-to)387-394
Number of pages8
JournalIUBMB life
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2004

Keywords

  • Beta cell
  • Cell death
  • Cytoprotection
  • Gene therapy
  • Islet transplantation
  • Protein transduction domains
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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