Prostatic involvement by urothelial carcinoma of the bladder: Clinicopathological features and outcome after radical cystectomy

Rajinikanth Ayyathurai, Pablo Gomez, Tony Luongo, Mark S. Soloway, Murugesan Manoharan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

OBJECTIVES: To review the long-term outcome of prostatic involvement in patients with bladder cancer (BC) treated with radical cystectomy (RC), as urothelial carcinoma (UC) involving the prostate occurs in such patients, and prostatic invasion by UC is by transmural invasion (contiguous), or when UC develops from the epithelium of the prostatic urethra (not contiguous). PATIENTS AND METHODS: Between 1992 and 2006, 351 men had RC for BC by one surgeon at our centre; they were stratified into those with contiguous or non-contiguous disease, based on prostatic stromal involvement. Relevant clinical and pathological data were collected and the survival analysed. RESULTS: In all, 24% (78/320) of the patients who had RC had prostatic involvement; 29 (9%) and 49 (15%) had contiguous and non-contiguous involvement, respectively. In the non-contiguous group, there was stromal and non-stromal UC involvement in 18 (37%) and 31 (63%), respectively. The overall 5-year survival of contiguous, non-contiguous and no prostatic involvement was 6%, 57% and 66% (P < 0.001). The 5-year overall survival of stromal and non-stromal UC was 26% and 74% (P = 0.008). There was no statistical difference in survival between contiguous and non-contiguous stromal involvement (P = 0.58). CONCLUSIONS: Prostatic UC with no stromal involvement did not alter the survival predicted by the primary bladder stage. Stromal involvement of the prostate has a poor prognosis regardless of the mode of invasion.

Original languageEnglish
Pages (from-to)1021-1025
Number of pages5
JournalBJU International
Volume100
Issue number5
DOIs
StatePublished - Nov 1 2007

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Cystectomy
Urinary Bladder
Carcinoma
Survival
Urinary Bladder Neoplasms
Prostate
Urethra
Epithelium

Keywords

  • Prostate
  • Radical cystectomy
  • Urothelial cancer

ASJC Scopus subject areas

  • Urology

Cite this

Prostatic involvement by urothelial carcinoma of the bladder : Clinicopathological features and outcome after radical cystectomy. / Ayyathurai, Rajinikanth; Gomez, Pablo; Luongo, Tony; Soloway, Mark S.; Manoharan, Murugesan.

In: BJU International, Vol. 100, No. 5, 01.11.2007, p. 1021-1025.

Research output: Contribution to journalArticle

Ayyathurai, Rajinikanth ; Gomez, Pablo ; Luongo, Tony ; Soloway, Mark S. ; Manoharan, Murugesan. / Prostatic involvement by urothelial carcinoma of the bladder : Clinicopathological features and outcome after radical cystectomy. In: BJU International. 2007 ; Vol. 100, No. 5. pp. 1021-1025.
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abstract = "OBJECTIVES: To review the long-term outcome of prostatic involvement in patients with bladder cancer (BC) treated with radical cystectomy (RC), as urothelial carcinoma (UC) involving the prostate occurs in such patients, and prostatic invasion by UC is by transmural invasion (contiguous), or when UC develops from the epithelium of the prostatic urethra (not contiguous). PATIENTS AND METHODS: Between 1992 and 2006, 351 men had RC for BC by one surgeon at our centre; they were stratified into those with contiguous or non-contiguous disease, based on prostatic stromal involvement. Relevant clinical and pathological data were collected and the survival analysed. RESULTS: In all, 24{\%} (78/320) of the patients who had RC had prostatic involvement; 29 (9{\%}) and 49 (15{\%}) had contiguous and non-contiguous involvement, respectively. In the non-contiguous group, there was stromal and non-stromal UC involvement in 18 (37{\%}) and 31 (63{\%}), respectively. The overall 5-year survival of contiguous, non-contiguous and no prostatic involvement was 6{\%}, 57{\%} and 66{\%} (P < 0.001). The 5-year overall survival of stromal and non-stromal UC was 26{\%} and 74{\%} (P = 0.008). There was no statistical difference in survival between contiguous and non-contiguous stromal involvement (P = 0.58). CONCLUSIONS: Prostatic UC with no stromal involvement did not alter the survival predicted by the primary bladder stage. Stromal involvement of the prostate has a poor prognosis regardless of the mode of invasion.",
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AU - Soloway, Mark S.

AU - Manoharan, Murugesan

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N2 - OBJECTIVES: To review the long-term outcome of prostatic involvement in patients with bladder cancer (BC) treated with radical cystectomy (RC), as urothelial carcinoma (UC) involving the prostate occurs in such patients, and prostatic invasion by UC is by transmural invasion (contiguous), or when UC develops from the epithelium of the prostatic urethra (not contiguous). PATIENTS AND METHODS: Between 1992 and 2006, 351 men had RC for BC by one surgeon at our centre; they were stratified into those with contiguous or non-contiguous disease, based on prostatic stromal involvement. Relevant clinical and pathological data were collected and the survival analysed. RESULTS: In all, 24% (78/320) of the patients who had RC had prostatic involvement; 29 (9%) and 49 (15%) had contiguous and non-contiguous involvement, respectively. In the non-contiguous group, there was stromal and non-stromal UC involvement in 18 (37%) and 31 (63%), respectively. The overall 5-year survival of contiguous, non-contiguous and no prostatic involvement was 6%, 57% and 66% (P < 0.001). The 5-year overall survival of stromal and non-stromal UC was 26% and 74% (P = 0.008). There was no statistical difference in survival between contiguous and non-contiguous stromal involvement (P = 0.58). CONCLUSIONS: Prostatic UC with no stromal involvement did not alter the survival predicted by the primary bladder stage. Stromal involvement of the prostate has a poor prognosis regardless of the mode of invasion.

AB - OBJECTIVES: To review the long-term outcome of prostatic involvement in patients with bladder cancer (BC) treated with radical cystectomy (RC), as urothelial carcinoma (UC) involving the prostate occurs in such patients, and prostatic invasion by UC is by transmural invasion (contiguous), or when UC develops from the epithelium of the prostatic urethra (not contiguous). PATIENTS AND METHODS: Between 1992 and 2006, 351 men had RC for BC by one surgeon at our centre; they were stratified into those with contiguous or non-contiguous disease, based on prostatic stromal involvement. Relevant clinical and pathological data were collected and the survival analysed. RESULTS: In all, 24% (78/320) of the patients who had RC had prostatic involvement; 29 (9%) and 49 (15%) had contiguous and non-contiguous involvement, respectively. In the non-contiguous group, there was stromal and non-stromal UC involvement in 18 (37%) and 31 (63%), respectively. The overall 5-year survival of contiguous, non-contiguous and no prostatic involvement was 6%, 57% and 66% (P < 0.001). The 5-year overall survival of stromal and non-stromal UC was 26% and 74% (P = 0.008). There was no statistical difference in survival between contiguous and non-contiguous stromal involvement (P = 0.58). CONCLUSIONS: Prostatic UC with no stromal involvement did not alter the survival predicted by the primary bladder stage. Stromal involvement of the prostate has a poor prognosis regardless of the mode of invasion.

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