Prostaglandins in physiological and in certain pathological responses of the cerebral circulation

H. A. Kontos, E. P. Wei, E. F. Ellis, W. Dalton Dietrich, J. T. Povlishock

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The most abundant prostaglandin produced by brain tissue varies from species to species. The most abundant prostaglandin produced by brain microvessels is PGI 2. PGG 2, PGH 2, PGI 2, PGE 2, PGD 2, and arachidonic acid dilated cerebral arterioles. Cyclooxygenase inhibitors (indomethacin, AHR-5850), in doses that reduced prostaglandin synthesis substantially, did not affect resting vascular caliber and did not influence the responses of cerebral arterioles to arterial hypoxia, arterial hypercapnia, or arterial hypocapnia, suggesting that prostaglandins are not involved in the mediation of these responses. The vasodilator action of vasoactive intestinal peptide on cerebral arterioles was blocked by these cyclooxygenase inhibitors. The cerebral arteriolar damage induced by fluid-percussion brain injury was inhibited by pretreatment with cyclooxygenase inhibitors, or with free radical scavengers. Topical application of arachidonic acid or PGG 2 reproduced the damage seen with brain injury. These findings show that prostaglandins are mediators of the cerebral arteriolar damage due to brain injury and that their mechanism of action is dependent on the generation of free oxygen radicals.

Original languageEnglish
Pages (from-to)2326-2330
Number of pages5
JournalFederation Proceedings
Volume40
Issue number8
StatePublished - Dec 1 1981
Externally publishedYes

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Cerebrovascular Circulation
Prostaglandins
Cyclooxygenase Inhibitors
Arterioles
Brain Injuries
Arachidonic Acid
Prostaglandin H2
Hypocapnia
Prostaglandins D
Percussion
Free Radical Scavengers
Hypercapnia
Vasoactive Intestinal Peptide
Brain
Prostaglandins E
Microvessels
Vasodilator Agents
Indomethacin
Free Radicals
Blood Vessels

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prostaglandins in physiological and in certain pathological responses of the cerebral circulation. / Kontos, H. A.; Wei, E. P.; Ellis, E. F.; Dalton Dietrich, W.; Povlishock, J. T.

In: Federation Proceedings, Vol. 40, No. 8, 01.12.1981, p. 2326-2330.

Research output: Contribution to journalArticle

Kontos, H. A. ; Wei, E. P. ; Ellis, E. F. ; Dalton Dietrich, W. ; Povlishock, J. T. / Prostaglandins in physiological and in certain pathological responses of the cerebral circulation. In: Federation Proceedings. 1981 ; Vol. 40, No. 8. pp. 2326-2330.
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