Prostaglandin F2α (PGF2α) was infused into a peripheral vein of six female volunteers during the luteal phase of their cycle. At an infusion rate of 25 to 46 μg/min., no effect was observed on peripheral plasma progesterone levels and luteal phase length. Vaginal spotting was a common occurrence. It is concluded from this study that at the days and rates of infusion used, PGF2α is not luteolytic in the non-pregnant woman.
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