Abstract
Prostanoids exhibit both pro-apoptotic and anti-apoptotic functions depending on the maturation stage and tissue localization of target cells. Prostaglandin (PG) E2 has been shown to protect T lymphocytes from TCR-mediated activation-induced cell death, but the mechanism by which PGE2 inhibits apoptosis of T cells has not been established. We show that this protection involves the down-regulation of Fas-ligand (Fas-L) mRNA levels in T cells. Modulation of cell surface Fas-L expressin by physiological concentrations of PGE2 was shown to be both anti-apoptotic as well as capable of inhibiting Fas-L-mediated cytotoxicity of Fas-transfected P815 target cells. Thus, this study provides direct evidence of the likely biological means by which PGE2 down-regulates T cell apoptosis.
Original language | English (US) |
---|---|
Pages (from-to) | 2360-2365 |
Number of pages | 6 |
Journal | European Journal of Immunology |
Volume | 29 |
Issue number | 7 |
DOIs | |
State | Published - 1999 |
Keywords
- Activation-induced cell death
- Apoptosis
- Fas ligand
- Prostaglandin E
- T cell
ASJC Scopus subject areas
- Immunology