Abstract
Objective: A prospective study of psychiatrically well Amish children to determine differences in the frequency and pattern of clinical features that may be prodromal for bipolar 1 disorder. Method: Children with a bipolar I parent (n = 100) and children of well parents in a matched control sample (n = 110) were assessed annually for 7 years with semistructured interviews covering medical/developmental features and symptoms/behaviors that are possibly prodromal for bipolarity. Randomized histories of these 210 children were evaluated blindly by 4 clinicians for independent ratings of risk for bipolarity. Results: Thirty-eight percent of the children of bipolar parents were rated as at risk compared with 17% of children in the control sample. Most control sample children with risk ratings had well parents with a bipolar sibling (i.e., family history positive). Children with family histories negative for mental illness rarely received even a low risk rating. Clinical features significantly (p ≤ .05) more frequent among children of a bipolar parent included mood lability, low energy, anxious/worried, hyper-alert, attention problems/distractible and school role impairment, easily excited, sensitivity, somatic complaints, and stubborn/determined. Conclusion: Mini-clusters of early possible predictors suggest a natural history of episodic prodromal features rather than the chronic symptom pattern sometimes described for children at risk for bipolar disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 786-796 |
| Number of pages | 11 |
| Journal | Journal of the American Academy of Child and Adolescent Psychiatry |
| Volume | 42 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2003 |
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Keywords
- Children-at-risk
- Pediatric bipolar
- Prodromal features
- Prospective study
ASJC Scopus subject areas
- Psychiatry and Mental health
- Developmental and Educational Psychology
Cite this
Prospective study of prodromal features for bipolarity in well Amish children. / Egeland, Janice; Shaw, Jon; Endicott, Jean; Pauls, David L.; Allen, Cleona R.; Hostetter, Abram M.; Sussex, James N.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 42, No. 7, 01.07.2003, p. 786-796.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prospective study of prodromal features for bipolarity in well Amish children
AU - Egeland, Janice
AU - Shaw, Jon
AU - Endicott, Jean
AU - Pauls, David L.
AU - Allen, Cleona R.
AU - Hostetter, Abram M.
AU - Sussex, James N.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Objective: A prospective study of psychiatrically well Amish children to determine differences in the frequency and pattern of clinical features that may be prodromal for bipolar 1 disorder. Method: Children with a bipolar I parent (n = 100) and children of well parents in a matched control sample (n = 110) were assessed annually for 7 years with semistructured interviews covering medical/developmental features and symptoms/behaviors that are possibly prodromal for bipolarity. Randomized histories of these 210 children were evaluated blindly by 4 clinicians for independent ratings of risk for bipolarity. Results: Thirty-eight percent of the children of bipolar parents were rated as at risk compared with 17% of children in the control sample. Most control sample children with risk ratings had well parents with a bipolar sibling (i.e., family history positive). Children with family histories negative for mental illness rarely received even a low risk rating. Clinical features significantly (p ≤ .05) more frequent among children of a bipolar parent included mood lability, low energy, anxious/worried, hyper-alert, attention problems/distractible and school role impairment, easily excited, sensitivity, somatic complaints, and stubborn/determined. Conclusion: Mini-clusters of early possible predictors suggest a natural history of episodic prodromal features rather than the chronic symptom pattern sometimes described for children at risk for bipolar disorder.
AB - Objective: A prospective study of psychiatrically well Amish children to determine differences in the frequency and pattern of clinical features that may be prodromal for bipolar 1 disorder. Method: Children with a bipolar I parent (n = 100) and children of well parents in a matched control sample (n = 110) were assessed annually for 7 years with semistructured interviews covering medical/developmental features and symptoms/behaviors that are possibly prodromal for bipolarity. Randomized histories of these 210 children were evaluated blindly by 4 clinicians for independent ratings of risk for bipolarity. Results: Thirty-eight percent of the children of bipolar parents were rated as at risk compared with 17% of children in the control sample. Most control sample children with risk ratings had well parents with a bipolar sibling (i.e., family history positive). Children with family histories negative for mental illness rarely received even a low risk rating. Clinical features significantly (p ≤ .05) more frequent among children of a bipolar parent included mood lability, low energy, anxious/worried, hyper-alert, attention problems/distractible and school role impairment, easily excited, sensitivity, somatic complaints, and stubborn/determined. Conclusion: Mini-clusters of early possible predictors suggest a natural history of episodic prodromal features rather than the chronic symptom pattern sometimes described for children at risk for bipolar disorder.
KW - Children-at-risk
KW - Pediatric bipolar
KW - Prodromal features
KW - Prospective study
UR - http://www.scopus.com/inward/record.url?scp=0041968778&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041968778&partnerID=8YFLogxK
U2 - 10.1097/01.CHI.0000046878.27264.12
DO - 10.1097/01.CHI.0000046878.27264.12
M3 - Article
C2 - 12819438
AN - SCOPUS:0041968778
VL - 42
SP - 786
EP - 796
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
SN - 0890-8567
IS - 7
ER -