Prospective evidence of a circadian rhythm for out-of-hospital cardiac arrests

Robert L. Levine

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Objectives. - Published studies have indicated a circadian rhythm in the occurrence of sudden cardiac death. However, these studies have involved either retrospective analyses of death certificates or analyses of data collected during studies of pharmacologic agents in selected populations. Purpose. - To determine whether a circadian pattern could be clearly demonstrated in a prospective study of out-of-hospital sudden cardiac death in a large, unselected population. Design. - All adult cases of sudden death of presumed primary cardiac cause from a large urban population were prospectively evaluated over a 12-month period. The incidence of sudden cardiac death was analyzed using harmonic regression of the data tabulated by hour of the day. Results. - During the year of study, 1019 consecutive primary cardiac arrests were analyzed. A significant circadian pattern was found (P<.0001) with the frequency of cardiac arrests increasing dramatically from 6 AM until noon. Conclusions. - This prospective study of out-of-hospital cardiac arrest confirms the existence of a circadian rhythm. These data have important implications for future investigations concerning the pathophysiology of sudden cardiac deaths.

Original languageEnglish
Pages (from-to)2935-2937
Number of pages3
JournalJournal of the American Medical Association
Volume267
Issue number21
StatePublished - Dec 1 1992

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Out-of-Hospital Cardiac Arrest
Sudden Cardiac Death
Circadian Rhythm
Heart Arrest
Prospective Studies
Death Certificates
Urban Population
Sudden Death
Population
Incidence

ASJC Scopus subject areas

  • Medicine(all)

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Prospective evidence of a circadian rhythm for out-of-hospital cardiac arrests. / Levine, Robert L.

In: Journal of the American Medical Association, Vol. 267, No. 21, 01.12.1992, p. 2935-2937.

Research output: Contribution to journalArticle

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