Prospective Evaluation of Focal High Intensity Focused Ultrasound for Localized Prostate Cancer

Bruno Nahar, Abhishek Bhat, Isildinha M. Reis, Nachiketh Soodana-Prakash, Maria F. Becerra, Diana Lopategui, Vivek Venkatramani, Ronak Patel, Vinayak Madhusoodanan, Oleksandr Kryvenko, Chad Ritch, Mark L Gonzalgo, Sanoj Punnen, Dipen J. Parekh

Research output: Contribution to journalArticle

Abstract

PURPOSE: We report short-term outcomes of focal high intensity focused ultrasound use for primary treatment of localized prostate cancer. MATERIALS AND METHODS: Single-center prospectively collected data on patients with prostate cancer who underwent primary focal high intensity focused ultrasound from January 2016 to July 2018 were included. All patients underwent a 12-core biopsy with magnetic resonance imaging-ultrasound fusion biopsy depending on the presence of targetable lesions. Any Grade Group was allowed, however only patients with localized disease were included. The primary outcome was oncologic control, defined as negative followup in-field biopsy of treated cancer. Prostate specific antigen, Sexual Health Inventory for Men, International Prostate Symptom Score and Expanded Prostate Cancer Index Composite domain scores were assessed 3-monthly till 12 months. Biopsy was performed at 6 or 12 months for high or low/intermediate risk cancer, respectively. RESULTS: Fifty-two patients with minimum followup of 12 months were included in the study. The majority of patients (67%) had cancer Grade Group 2 or greater. Fifteen patients (28.8%) underwent complete transurethral prostate resection/holmium laser enucleation of prostate procedure for debulking large prostates to avoid postoperative urinary retention. Among 30 (58%) patients who underwent followup biopsies, 25 (83%) had negative in-field biopsy results and 4 (13%) had de-novo positive out-of-field biopsy. Only 5 major complications (all grade III) in 4 patients were noted. Urinary symptoms returned to near baseline questionnaire scores within 3-6 months. Sexual function returned to baseline at 12 months. CONCLUSIONS: Focal high intensity focused ultrasound is a safe and effective treatment for patients with localized clinically significant prostate cancer with acceptable short-term oncologic and functional outcomes. The complications are minimal and patient selection is essential. Short-term oncologic outcomes are promising but longer followup is required to establish long-term oncologic outcomes.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalThe Journal of urology
Volume204
Issue number3
DOIs
StatePublished - Sep 1 2020

Keywords

  • prostatic neoplasms
  • treatment outcome
  • ultrasound

ASJC Scopus subject areas

  • Urology

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