Propylthiouracil-induced acute liver failure: Role of liver transplantation

Andres F. Carrion, Frank Czul, Leopoldo R. Arosemena, Gennaro Selvaggi, Monica T. Garcia, Akin Tekin, Andreas G. Tzakis, Paul Martin, Ravi K. Ghanta

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Propylthiouracil- (PTU-) induced hepatotoxicity is rare but potentially lethal with a spectrum of liver injury ranging from asymptomatic elevation of transaminases to fulminant hepatic failure and death. We describe two cases of acute hepatic failure due to PTU that required liver transplantation. Differences in the clinical presentation, histological characteristics, and posttransplant management are described as well as alternative therapeutic options. Frequent monitoring for PTU-induced hepatic dysfunction is strongly advised because timely discontinuation of this drug and implementation of noninvasive therapeutic interventions may prevent progression to liver failure or even death.

Original languageEnglish (US)
Article number910636
JournalInternational Journal of Endocrinology
Volume2010
DOIs
StatePublished - 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

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