Propranolol effects on autonomic function in hypertensive men

D. T. O'Connor, R. A. Preston

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Beta blocker antihypertensive effects are incompletely understood, and may involve alterations in the autonomic nervous system. We studied autonomic function in 12 essential hypertensive men during treatment with placebo and chronic oral propranolol. Propranolol reduced blood pressure and heart rate (both p<0.01) with an associated increase in baroreflex sensitivity during phenylephrine testing (p<0.02), though amyl nitrite-tested baroreflex sensitivity was unchanged; blood pressure decrement did not correlate with baroreflex enhancement. Response to the cold pressor test and the blood pressure decrement to phentolamine alpha blockade were unaltered by propranolol, suggesting unchanged efferent sympathetic function; nor were several biochemical indices of sympathetic nervous activity influenced by propranolol. Propranol does perturb autonomic function in man, but the perturbations do not correlate with blood pressure decrement; nor are physiologic or biochemical indices of efferent sympathetic activity reduced by propranolol.

Original languageEnglish (US)
Pages (from-to)340-346
Number of pages7
JournalClinical Cardiology
Volume5
Issue number5
DOIs
StatePublished - May 1982
Externally publishedYes

Keywords

  • Hypertension
  • Propranolol
  • autonomic nervous system
  • baroreflexes
  • dopamine‐β‐hydroxylase
  • rennin
  • sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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