Propranolol effects on autonomic function in hypertensive men

D. T. O'Connor, Richard A Preston

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Beta blocker antihypertensive effects are incompletely understood, and may involve alterations in the autonomic nervous system. We studied autonomic function in 12 essential hypertensive men during treatment with placebo and chronic oral propranolol. Propranolol reduced blood pressure and heart rate (both p<0.01) with an associated increase in baroreflex sensitivity during phenylephrine testing (p<0.02), though amyl nitrite-tested baroreflex sensitivity was unchanged; blood pressure decrement did not correlate with baroreflex enhancement. Response to the cold pressor test and the blood pressure decrement to phentolamine alpha blockade were unaltered by propranolol, suggesting unchanged efferent sympathetic function; nor were several biochemical indices of sympathetic nervous activity influenced by propranolol. Propranol does perturb autonomic function in man, but the perturbations do not correlate with blood pressure decrement; nor are physiologic or biochemical indices of efferent sympathetic activity reduced by propranolol.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalClinical Cardiology
Volume5
Issue number5
StatePublished - Jan 1 1982
Externally publishedYes

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Propranolol
Baroreflex
Blood Pressure
Amyl Nitrite
Phentolamine
Autonomic Nervous System
Phenylephrine
Antihypertensive Agents
Heart Rate
Placebos
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Propranolol effects on autonomic function in hypertensive men. / O'Connor, D. T.; Preston, Richard A.

In: Clinical Cardiology, Vol. 5, No. 5, 01.01.1982, p. 340-346.

Research output: Contribution to journalArticle

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