Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism.

L. Stewart, Ross Bullock, C. Rafferty, W. Fitch, G. M. Teasdale

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have compared the effects of an intravenous infusion of propofol with those of morphine and midazolam on global brain metabolism (AVDO2) and brain perfusion following severe head injury. Fifteen patients were sedated with either a continuous infusion of propofol (mean rate 232 mg/h, range 150-400 mg/h) or infusions of morphine (mean rate 2.3 mg/h, range 0-4 mg/h) and midazolam (mean rate 2.8 mg/h, range 0-5 mg/h). Both groups were well matched for sex, age and level of coma (Glasgow coma scale) prior to sedation. Continuous data collection of AVDO2, mean arterial blood pressure (MABP), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) began at 12 hours post injury and continued for a mean period of 40 hours. Morphine and midazolam did not have a significant effect on any of the measured parameters. Propofol led to a fall in AVDO2 from 6.0 +/- 2.6 ml/dl to 3.0 +/- 0.6 ml/dl at 4 hours. However, there was no effect on MABP, ICP or CPP. Outcome was similar in the 2 groups.

Original languageEnglish
Pages (from-to)544-546
Number of pages3
JournalActa neurochirurgica. Supplementum
Volume60
StatePublished - Dec 1 1994
Externally publishedYes

Fingerprint

intracranial pressure
Midazolam
Blood pressure
Intracranial Pressure
Propofol
metabolism
Craniocerebral Trauma
Metabolism
Morphine
brain
Brain
Cerebrovascular Circulation
Arterial Pressure
morphine
blood pressure
coma
Glasgow Coma Scale
Coma
Intravenous Infusions
Perfusion

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Stewart, L., Bullock, R., Rafferty, C., Fitch, W., & Teasdale, G. M. (1994). Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism. Acta neurochirurgica. Supplementum, 60, 544-546.

Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism. / Stewart, L.; Bullock, Ross; Rafferty, C.; Fitch, W.; Teasdale, G. M.

In: Acta neurochirurgica. Supplementum, Vol. 60, 01.12.1994, p. 544-546.

Research output: Contribution to journalArticle

Stewart, L, Bullock, R, Rafferty, C, Fitch, W & Teasdale, GM 1994, 'Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism.', Acta neurochirurgica. Supplementum, vol. 60, pp. 544-546.
Stewart, L. ; Bullock, Ross ; Rafferty, C. ; Fitch, W. ; Teasdale, G. M. / Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism. In: Acta neurochirurgica. Supplementum. 1994 ; Vol. 60. pp. 544-546.
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