Prophylaxis against herpes labialis with acyclovir cream – a placebo-controlled study

J. R. Gibson, M. R. Klaber, S. G. Harvey, A. Tosti, D. Jones, J. M. Yeo

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Patients with 6 or more recurrences per year of herpes labialis were entered into a randomized, double-blind, placebo-controlled, crossover study. During the trial, they applied acyclovir cream for 16 weeks and placebo cream for 16 weeks to all previously affected areas 4 times per day, and were subsequently observed for further 16 weeks with no treatment. Results from the 23 evaluable cases showed that although recurrences did occur whilst on acyclovir treatment, patients suffered from significantly fewer days of disease and significantly fewer attacks of cold sores when compared with placebo.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
Issue number2
StatePublished - 1986
Externally publishedYes


  • Acyclovir cream
  • Prophylaxis against herpes labialis

ASJC Scopus subject areas

  • Dermatology


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