Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study

J. R. Gibson, M. R. Klaber, S. G. Harvey, Antonella Tosti, D. Jones, J. M. Yeo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Patients with 6 or more recurrences per year of herpes labialis were entered into a randomized, double-blind, placebo-controlled, crossover study. During the trial, they applied acyclovir cream for 16 weeks and placebo cream for 16 weeks to all previously affected areas 4 times per day, and were subsequently observed for further 16 weeks with no treatment. Results from the 23 evaluable cases showed that although recurrences did occur whilst on acyclovir treatment, patients suffered from significantly fewer days of disease and significantly fewer attacks of cold sores when compared with placebo.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalDermatologica
Volume172
Issue number2
StatePublished - May 1 1986
Externally publishedYes

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Herpes Labialis
Acyclovir
Placebos
Recurrence
Cross-Over Studies
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Gibson, J. R., Klaber, M. R., Harvey, S. G., Tosti, A., Jones, D., & Yeo, J. M. (1986). Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study. Dermatologica, 172(2), 104-107.

Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study. / Gibson, J. R.; Klaber, M. R.; Harvey, S. G.; Tosti, Antonella; Jones, D.; Yeo, J. M.

In: Dermatologica, Vol. 172, No. 2, 01.05.1986, p. 104-107.

Research output: Contribution to journalArticle

Gibson, JR, Klaber, MR, Harvey, SG, Tosti, A, Jones, D & Yeo, JM 1986, 'Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study', Dermatologica, vol. 172, no. 2, pp. 104-107.
Gibson JR, Klaber MR, Harvey SG, Tosti A, Jones D, Yeo JM. Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study. Dermatologica. 1986 May 1;172(2):104-107.
Gibson, J. R. ; Klaber, M. R. ; Harvey, S. G. ; Tosti, Antonella ; Jones, D. ; Yeo, J. M. / Prophylaxis against herpes labialis with acyclovir cream - A placebo-controlled study. In: Dermatologica. 1986 ; Vol. 172, No. 2. pp. 104-107.
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