Prophylactic use of lidocaine to prevent advanced ventricular arrhythmias during pulmonary artery catheterization. Prospective double-blind study

Charles L. Sprung, Eileen H. Marcial, Armando A. Garcia, Rafael F. Sequeira, Richard G. Pozen

Research output: Contribution to journalArticle

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Abstract

To determine whether prophylactic lidocaine could decrease the incidence of advanced ventricular arrhythmias, 62 patients undergoing 67 pulmonary artery catheterizations were given lidocaine or placebo before and during catheterization. Advanced ventricular arrhythmias occurred in 42 of the 67 catheterizations (63 percent). In 18 of 31 patients receiving lidocaine (58 percent) arrhythmias developed, whereas 24 of 36 patients who received placebo (67 percent) had evidence of arrhythmias. These differences were not significant. However, patients with catheterization times of less than 20 minutes who were treated with lidocaine had less ectopy (25 percent) than patients treated with placebo (68 percent) (p < 0.05). Two patients had sustained ventricular tachycardia and both were receiving placebo. No complications of lidocaine prophylaxis were noted. Prophylactic lidocaine appears to decrease the incidence of mechanically induced arrhythmias in critically ill patients undergoing catheterization that is not prolonged.

Original languageEnglish
Pages (from-to)906-910
Number of pages5
JournalThe American Journal of Medicine
Volume75
Issue number6
DOIs
StatePublished - Jan 1 1983

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Swan-Ganz Catheterization
Lidocaine
Double-Blind Method
Cardiac Arrhythmias
Catheterization
Placebos
Incidence
Ventricular Tachycardia
Critical Illness

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Prophylactic use of lidocaine to prevent advanced ventricular arrhythmias during pulmonary artery catheterization. Prospective double-blind study. / Sprung, Charles L.; Marcial, Eileen H.; Garcia, Armando A.; Sequeira, Rafael F.; Pozen, Richard G.

In: The American Journal of Medicine, Vol. 75, No. 6, 01.01.1983, p. 906-910.

Research output: Contribution to journalArticle

Sprung, Charles L. ; Marcial, Eileen H. ; Garcia, Armando A. ; Sequeira, Rafael F. ; Pozen, Richard G. / Prophylactic use of lidocaine to prevent advanced ventricular arrhythmias during pulmonary artery catheterization. Prospective double-blind study. In: The American Journal of Medicine. 1983 ; Vol. 75, No. 6. pp. 906-910.
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