Prophylactic Antibiotic Management of Surgical Patients Noted as "Allergic" to Penicillin at Two Academic Hospitals

Richard H. Epstein, Paul St Jacques, Jonathan P. Wanderer, Mark R. Bombulie, Niraj Agarwalla

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We studied prophylactic antibiotics administered at 2 academic medical centers during a 6-year period where a cephalosporin was indicated but an "allergy" to penicillin was noted. Another drug (typically vancomycin or clindamycin) was substituted approximately 80% of the time; this occurred frequently even when symptoms unrelated to acute hypersensitivity were listed. In >50% of cases, the reaction was either omitted or vague (e.g., simply "rash"). Given the estimated 1% cross-reactivity between penicillins and cephalosporins with similar R1 side chains, many of these patients could have received either the prescribed cephalosporin or another cephalosporin with a different R1 side chain.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalA & A case reports
Volume6
Issue number9
DOIs
StatePublished - May 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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