Properties of H-2L locus products in allogeneic and H-2 restricted, trinitrophyl-specific cytotoxic responses

Robert B Levy, G. M. Sheare, T. H. Hansen

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Abstract

The role of the recently defined L antigen (a second D region product) in allogeneic and TNP-specific syngeneic primary CML responses has been investigated. The lysis by anti-L specific cytotoxic effector cells was not inhibited when the target cells were pretreated with an antiserum directed against K and D, whereas an antiserum against L completely abrogated this response. Therefore, H-2L products are recognized on the target cells independently of H-2K and H-2D locus products. Both A.SW cells as well as B10 cells were found to respond to L(d) alloantigens, in addition to D(d) alloantigens when stimulated by cells differing only in the D region. The results of cold target blocking and antiserum inhibition experiments failed to detect cytotoxic cells with specificity for L antigens in association with TNP, under conditions in which TNP specific effectors to K and D antigens were demonstrable. These findings suggest that there is a more limited involvement if H-2L locus products than the H-2K or H-2D locus products in the induction and specificity of these responses.

Original languageEnglish
Pages (from-to)2263-2269
Number of pages7
JournalJournal of Immunology
Volume121
Issue number6
StatePublished - Dec 1 1978
Externally publishedYes

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Immune Sera
Isoantigens
antigen L
K antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Properties of H-2L locus products in allogeneic and H-2 restricted, trinitrophyl-specific cytotoxic responses. / Levy, Robert B; Sheare, G. M.; Hansen, T. H.

In: Journal of Immunology, Vol. 121, No. 6, 01.12.1978, p. 2263-2269.

Research output: Contribution to journalArticle

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N2 - The role of the recently defined L antigen (a second D region product) in allogeneic and TNP-specific syngeneic primary CML responses has been investigated. The lysis by anti-L specific cytotoxic effector cells was not inhibited when the target cells were pretreated with an antiserum directed against K and D, whereas an antiserum against L completely abrogated this response. Therefore, H-2L products are recognized on the target cells independently of H-2K and H-2D locus products. Both A.SW cells as well as B10 cells were found to respond to L(d) alloantigens, in addition to D(d) alloantigens when stimulated by cells differing only in the D region. The results of cold target blocking and antiserum inhibition experiments failed to detect cytotoxic cells with specificity for L antigens in association with TNP, under conditions in which TNP specific effectors to K and D antigens were demonstrable. These findings suggest that there is a more limited involvement if H-2L locus products than the H-2K or H-2D locus products in the induction and specificity of these responses.

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