Proopiomelanocortin expression in the skin during induced hair growth in mice

A. Slominski, Ralf Paus, J. Mazurkiewicz

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

Original languageEnglish (US)
Pages (from-to)50-54
Number of pages5
JournalExperientia
Volume48
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Pro-Opiomelanocortin
Hair
Endorphins
Skin
Growth
Sebaceous Glands
Northern Blotting
Proteins
Western Blotting
Immunohistochemistry
Gene Expression
Antigens
Messenger RNA

Keywords

  • β-endorphin
  • C57B1/6 mice
  • hair growth
  • Proopiomelanocortin
  • skin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Proopiomelanocortin expression in the skin during induced hair growth in mice. / Slominski, A.; Paus, Ralf; Mazurkiewicz, J.

In: Experientia, Vol. 48, No. 1, 01.01.1992, p. 50-54.

Research output: Contribution to journalArticle

Slominski, A. ; Paus, Ralf ; Mazurkiewicz, J. / Proopiomelanocortin expression in the skin during induced hair growth in mice. In: Experientia. 1992 ; Vol. 48, No. 1. pp. 50-54.
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