Abstract
We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Experientia |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
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Keywords
- β-endorphin
- C57B1/6 mice
- hair growth
- Proopiomelanocortin
- skin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Proopiomelanocortin expression in the skin during induced hair growth in mice. / Slominski, A.; Paus, Ralf; Mazurkiewicz, J.
In: Experientia, Vol. 48, No. 1, 01.01.1992, p. 50-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proopiomelanocortin expression in the skin during induced hair growth in mice
AU - Slominski, A.
AU - Paus, Ralf
AU - Mazurkiewicz, J.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.
AB - We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.
KW - β-endorphin
KW - C57B1/6 mice
KW - hair growth
KW - Proopiomelanocortin
KW - skin
UR - http://www.scopus.com/inward/record.url?scp=0026541440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026541440&partnerID=8YFLogxK
U2 - 10.1007/BF01923606
DO - 10.1007/BF01923606
M3 - Article
VL - 48
SP - 50
EP - 54
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
SN - 1420-682X
IS - 1
ER -