Proopiomelanocortin expression in the skin during induced hair growth in mice

A. Slominski; R. Paus; J. Mazurkiewicz

doi:10.1007/BF01923606

Proopiomelanocortin expression in the skin during induced hair growth in mice

A. Slominski, R. Paus, J. Mazurkiewicz

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

Original language	English (US)
Pages (from-to)	50-54
Number of pages	5
Journal	Experientia
Volume	48
Issue number	1
DOIs	https://doi.org/10.1007/BF01923606
State	Published - Jan 1 1992
Externally published	Yes

Keywords

C57B1/6 mice
Proopiomelanocortin
hair growth
skin
β-endorphin

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/BF01923606

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title = "Proopiomelanocortin expression in the skin during induced hair growth in mice",

abstract = "We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.",

keywords = "C57B1/6 mice, Proopiomelanocortin, hair growth, skin, β-endorphin",

author = "A. Slominski and R. Paus and J. Mazurkiewicz",

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T1 - Proopiomelanocortin expression in the skin during induced hair growth in mice

AU - Slominski, A.

AU - Paus, R.

AU - Mazurkiewicz, J.

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Y1 - 1992/1/1

N2 - We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

AB - We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

KW - C57B1/6 mice

KW - Proopiomelanocortin

KW - hair growth

KW - skin

KW - β-endorphin

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