Abstract
We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti β-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, β-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Experientia |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1992 |
| Externally published | Yes |
Keywords
- C57B1/6 mice
- Proopiomelanocortin
- hair growth
- skin
- β-endorphin
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Slominski, A., Paus, R., & Mazurkiewicz, J. (1992). Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia, 48(1), 50-54. https://doi.org/10.1007/BF01923606