Promotion of graft survival by photothrombotic occlusion of corneal neovascularization

G. Corrent, T. J. Roussel, S. C G Tseng, B. D. Watson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Corneal neovascularization may reduce the success of penetrating keratoplasty. Photothrombosis using intravenous rose bengal and argon laser irradiation has shown promise for occluding corneal vessels. It is therefore conceivable that photothrombosis can improve the graft survival in vascularized corneas. Using intracorneal 7-0 silk sutures as the stimuli, corneal neovascularization was induced in 1 eye each of 19 New Zealand white rabbits. Eleven eyes received photothrombosis. Successful occlusion with subsequent regression was verified by corneal fluorescein angiography. Three were assigned for observation. Six of 8 eyes receiving grafts from an outbred rabbit donor after photothrombosis remained clear during 6.5 to 18.5 weeks of follow-up, while vascularization and opacity occurred in 7 of 8 control eyes without photothrombosis. These results indicate that prior photothrombotic occlusion of corneal vessels can significantly improve graft survival in this experimental model and may have clinical applications.

Original languageEnglish
Pages (from-to)1501-1506
Number of pages6
JournalArchives of Ophthalmology
Volume107
Issue number10
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Corneal Neovascularization
Graft Survival
Rabbits
Rose Bengal
Penetrating Keratoplasty
Silk
Fluorescein Angiography
Argon
Cornea
Sutures
Lasers
Theoretical Models
Observation
Transplants

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Corrent, G., Roussel, T. J., Tseng, S. C. G., & Watson, B. D. (1989). Promotion of graft survival by photothrombotic occlusion of corneal neovascularization. Archives of Ophthalmology, 107(10), 1501-1506.

Promotion of graft survival by photothrombotic occlusion of corneal neovascularization. / Corrent, G.; Roussel, T. J.; Tseng, S. C G; Watson, B. D.

In: Archives of Ophthalmology, Vol. 107, No. 10, 01.01.1989, p. 1501-1506.

Research output: Contribution to journalArticle

Corrent, G, Roussel, TJ, Tseng, SCG & Watson, BD 1989, 'Promotion of graft survival by photothrombotic occlusion of corneal neovascularization', Archives of Ophthalmology, vol. 107, no. 10, pp. 1501-1506.
Corrent G, Roussel TJ, Tseng SCG, Watson BD. Promotion of graft survival by photothrombotic occlusion of corneal neovascularization. Archives of Ophthalmology. 1989 Jan 1;107(10):1501-1506.
Corrent, G. ; Roussel, T. J. ; Tseng, S. C G ; Watson, B. D. / Promotion of graft survival by photothrombotic occlusion of corneal neovascularization. In: Archives of Ophthalmology. 1989 ; Vol. 107, No. 10. pp. 1501-1506.
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