Promiscuous expression of myosin in myotonic dystrophy

G. E. Moore, A. D. Roses, Margaret A Pericak-Vance, W. E. Garrett, F. H. Schachat

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The pathologic changes in myotonic dystrophy (DM) skeletal muscle biopsies have been analyzed at both the histochemical and molecular level. A histochemical stain for pretyping single fibers in conjunction with sodium dodecyl sulphate-polyacrylamide gel electrophoresis allowed biochemical differences to be pinpointed in specific histochemical fiber types. These biochemical differences can be related to histochemical changes in fiber type observed in cross-section of the DM biopsies. Such changes included specific fiber type atrophy, hypertrophy, and disproportion. The pathogenesis of DM appears to be characterized by a large increase in the number of promiscuous fibers, that is, those fibers that express both fast and slow myosins. This promiscuity, which is rare in control muscle (<2%), is also prevalent at high levels in some family members at risk for DM. The observed promiscuity, although probably not a primary effect of DM, appears to be linked to the histochemical changes in fiber type observed in the DM biopsies.

Original languageEnglish
Pages (from-to)355-363
Number of pages9
JournalMuscle and Nerve
Volume9
Issue number4
StatePublished - Jul 16 1986
Externally publishedYes

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Myotonic Dystrophy
Myosins
Biopsy
Sodium Dodecyl Sulfate
Hypertrophy
Atrophy
Polyacrylamide Gel Electrophoresis
Skeletal Muscle
Coloring Agents
Muscles

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Moore, G. E., Roses, A. D., Pericak-Vance, M. A., Garrett, W. E., & Schachat, F. H. (1986). Promiscuous expression of myosin in myotonic dystrophy. Muscle and Nerve, 9(4), 355-363.

Promiscuous expression of myosin in myotonic dystrophy. / Moore, G. E.; Roses, A. D.; Pericak-Vance, Margaret A; Garrett, W. E.; Schachat, F. H.

In: Muscle and Nerve, Vol. 9, No. 4, 16.07.1986, p. 355-363.

Research output: Contribution to journalArticle

Moore, GE, Roses, AD, Pericak-Vance, MA, Garrett, WE & Schachat, FH 1986, 'Promiscuous expression of myosin in myotonic dystrophy', Muscle and Nerve, vol. 9, no. 4, pp. 355-363.
Moore GE, Roses AD, Pericak-Vance MA, Garrett WE, Schachat FH. Promiscuous expression of myosin in myotonic dystrophy. Muscle and Nerve. 1986 Jul 16;9(4):355-363.
Moore, G. E. ; Roses, A. D. ; Pericak-Vance, Margaret A ; Garrett, W. E. ; Schachat, F. H. / Promiscuous expression of myosin in myotonic dystrophy. In: Muscle and Nerve. 1986 ; Vol. 9, No. 4. pp. 355-363.
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