Promiscuous expression of myosin in myotonic dystrophy

Gudrun E. Moore, Allen D. Roses, Margaret A. Pericak‐vance, William E. Garrett, Frederick H. Schachat

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The pathologic changes in myotonic dystrophy (DM) skeletal muscle biopsies have been analyzed at both the histochemical and molecular level. A histochemical stain for pretyping single fibers in conjunction with sodium dodecyl sulphate-polyacrylamide gel electrophoresis allowed biochemical differences to be pinpointed in specific histochemical fiber types. These biochemical differences can be related to histochemical changes in fiber type observed in cross-section of the DM biopsies. Such changes included specific fiber type atrophy, hypertrophy, and disproportion. The pathogenesis of DM appears to be characterized by a large increase in the number of promiscuous fibers, that is, those fibers that express both fast and slow myosins. This promiscuity, which is rare in control muscle (<2%), is also prevalent at high levels in some family members at risk for DM. The observed promiscuity, although probably not a primary effect of DM, appears to be linked to the histochemical changes in fiber type observed in the DM biopsies.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalMuscle & Nerve
Volume9
Issue number4
DOIs
StatePublished - May 1986
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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    Moore, G. E., Roses, A. D., Pericak‐vance, M. A., Garrett, W. E., & Schachat, F. H. (1986). Promiscuous expression of myosin in myotonic dystrophy. Muscle & Nerve, 9(4), 355-363. https://doi.org/10.1002/mus.880090413