Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU6, desGly-NH210]-LH-RH Ethylamide

Jesus A. Vilchez-Martinez, Escipion Pedroza, David H. Coy, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume154
Issue number3
DOIs
StatePublished - Mar 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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