Abstract
LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.
| Original language | English |
|---|---|
| Pages (from-to) | 427-430 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 154 |
| Issue number | 3 |
| State | Published - Dec 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide. / Vilchez-Martinez, J. A.; Pedroza, E.; Coy, D. H.; Arimura, A.; Schally, Andrew V.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 154, No. 3, 01.12.1977, p. 427-430.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide
AU - Vilchez-Martinez, J. A.
AU - Pedroza, E.
AU - Coy, D. H.
AU - Arimura, A.
AU - Schally, Andrew V
PY - 1977/12/1
Y1 - 1977/12/1
N2 - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.
AB - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.
UR - http://www.scopus.com/inward/record.url?scp=0017694587&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017694587&partnerID=8YFLogxK
M3 - Article
C2 - 322156
AN - SCOPUS:0017694587
VL - 154
SP - 427
EP - 430
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 3
ER -