Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU6, desGly-NH210]-LH-RH Ethylamide

Jesus A. Vilchez-Martinez; Escipion Pedroza; David H. Coy; Akira Arimura; Andrew V. Schally

doi:10.3181/00379727-154-39686

Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU⁶, desGly-NH₂¹⁰]-LH-RH Ethylamide

Jesus A. Vilchez-Martinez, Escipion Pedroza, David H. Coy, Akira Arimura, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

LH and FSH releasing activities of [D Leu ⁶, desGly NH ₂ ¹⁰] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu ⁶, desGly NH ₂ ¹⁰] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu ⁶, desGly NH ₂ ¹⁰] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

Original language	English (US)
Pages (from-to)	427-430
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	154
Issue number	3
DOIs	https://doi.org/10.3181/00379727-154-39686
State	Published - Mar 1977
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU⁶, desGly-NH₂¹⁰]-LH-RH Ethylamide. / Vilchez-Martinez, Jesus A.; Pedroza, Escipion; Coy, David H.; Arimura, Akira; Schally, Andrew V.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 154, No. 3, 03.1977, p. 427-430.

Research output: Contribution to journal › Article › peer-review

@article{a562decccd7b49acadc0f722f7b87b5e,

title = "Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU6, desGly-NH210]-LH-RH Ethylamide",

abstract = "LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.",

author = "Vilchez-Martinez, {Jesus A.} and Escipion Pedroza and Coy, {David H.} and Akira Arimura and Schally, {Andrew V.}",

note = "Funding Information: This work was supported by NICHHD Contract 72-2741, U.S.P.H.S. Grants AM 07467 and HD 06555, and the Veterans Administration.",

year = "1977",

month = mar,

doi = "10.3181/00379727-154-39686",

language = "English (US)",

volume = "154",

pages = "427--430",

journal = "Experimental Biology and Medicine",

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T1 - Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU6, desGly-NH210]-LH-RH Ethylamide

AU - Vilchez-Martinez, Jesus A.

AU - Pedroza, Escipion

AU - Coy, David H.

AU - Arimura, Akira

AU - Schally, Andrew V.

N1 - Funding Information: This work was supported by NICHHD Contract 72-2741, U.S.P.H.S. Grants AM 07467 and HD 06555, and the Veterans Administration.

PY - 1977/3

Y1 - 1977/3

N2 - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

AB - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

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JO - Experimental Biology and Medicine

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Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU⁶, desGly-NH₂¹⁰]-LH-RH Ethylamide

Abstract

ASJC Scopus subject areas

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