Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide

J. A. Vilchez-Martinez, E. Pedroza, D. H. Coy, A. Arimura, Andrew V Schally

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

Original languageEnglish
Pages (from-to)427-430
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume154
Issue number3
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Pituitary Gonadotropins
Gonadotropin-Releasing Hormone
Gonadotropins
Rats
Injections
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide. / Vilchez-Martinez, J. A.; Pedroza, E.; Coy, D. H.; Arimura, A.; Schally, Andrew V.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 154, No. 3, 01.12.1977, p. 427-430.

Research output: Contribution to journalArticle

@article{a562decccd7b49acadc0f722f7b87b5e,
title = "Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide",
abstract = "LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.",
author = "Vilchez-Martinez, {J. A.} and E. Pedroza and Coy, {D. H.} and A. Arimura and Schally, {Andrew V}",
year = "1977",
month = "12",
day = "1",
language = "English",
volume = "154",
pages = "427--430",
journal = "Experimental Biology and Medicine",
issn = "0037-9727",
publisher = "Society for Experimental Biology and Medicine",
number = "3",

}

TY - JOUR

T1 - Prolonged release of LH and FSH and depletion of pituitary gonadotropin content after administration of [D LEU 6, desGly NH 2 10] LH RH ethylamide

AU - Vilchez-Martinez, J. A.

AU - Pedroza, E.

AU - Coy, D. H.

AU - Arimura, A.

AU - Schally, Andrew V

PY - 1977/12/1

Y1 - 1977/12/1

N2 - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

AB - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.

UR - http://www.scopus.com/inward/record.url?scp=0017694587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017694587&partnerID=8YFLogxK

M3 - Article

C2 - 322156

AN - SCOPUS:0017694587

VL - 154

SP - 427

EP - 430

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 0037-9727

IS - 3

ER -