TY - JOUR
T1 - Prolonged Release of LH and FSH and Depletion of Pituitary Gonadotropin Content after Administration of [d-LEU6, desGly-NH210]-LH-RH Ethylamide
AU - Vilchez-Martinez, Jesus A.
AU - Pedroza, Escipion
AU - Coy, David H.
AU - Arimura, Akira
AU - Schally, Andrew V.
N1 - Funding Information:
This work was supported by NICHHD Contract 72-2741, U.S.P.H.S. Grants AM 07467 and HD 06555, and the Veterans Administration.
PY - 1977/3
Y1 - 1977/3
N2 - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.
AB - LH and FSH releasing activities of [D Leu 6, desGly NH 2 10] LH RH ethylamide were examined using immature male rats. The gonadotropin release induced by various doses of [D Leu 6, desGly NH 2 10] LH RH ethylamide followed a different pattern than when LH RH was given, reaching a peak at 2 hr after injections, serum LH and FSH being still elevated at 4 hr. In contrast the LH and FSH release induced by LH RH reached a peak in 15 min and declined at 1 hr. This provides further evidence that this analog is indeed long acting. The LH RH analog had a potency 20 to 60 times greater for LH release and 10 to 30 times higher for FSH release than LH RH. [D Leu 6, desGly NH 2 10] LH RH ethylamide also caused a significant depletion of the pituitary gonadotropin content.
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U2 - 10.3181/00379727-154-39686
DO - 10.3181/00379727-154-39686
M3 - Article
C2 - 322156
AN - SCOPUS:0017694587
VL - 154
SP - 427
EP - 430
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 0037-9727
IS - 3
ER -