Prolonged intrahepatic cholestasis secondary to acute hepatitis A

S. C. Gordon, K. R. Reddy, L. Schiff, E. R. Schiff

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Viral hepatitis characterized by prolonged cholestasis has not been associated with a specific serologic marker. We report the cases of six patients presenting with a clinical syndrome typical of cholestatic hepatitis who were subsequently found to have acute hepatitis A. Usual features include pruritus, fever, diarrhea, and weight loss with serum bilirubin levels greater than 10 mg/dL, and a clinical course lasting at least 12 weeks. All patients recovered completely without sequelae. Knowledge of this unusual manifestation of hepatitis A may help avoid potentially invasive procedures involved in the evaluation of suspected obstructive jaundice and facilitate appropriate immunoprophylactic measures.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalAnnals of internal medicine
Issue number5
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Internal Medicine


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