Prolonged elevation of luteinizing hormone (LH) after intranasal administration of an analog of LH releasing hormone

D. Gonzalez-Barcena; A. J. Kastin; D. S. Schalch; D. H. Coy; A. V. Schally

doi:10.1016/S0015-0282(16)42190-4

Prolonged elevation of luteinizing hormone (LH) after intranasal administration of an analog of LH releasing hormone

D. Gonzalez-Barcena, A. J. Kastin, D. S. Schalch, D. H. Coy, A. V. Schally

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

[D Leu 6, desGly NH ₂ 10] LH RH ethylamide, an analog of the luteinizing hormone releasing hormone (LH RH), was administered by intranasal spray or tube to 18 healthy men. A significant release of LH occurred within 15 minutes and was sustained for as long as 12 hours in what appeared to be a biphasic response. Both the spray and rhinyl tube were shown to be effective methods for releasing LH by intranasal administration of the LH RH analog.

Original language	English (US)
Pages (from-to)	1246-1249
Number of pages	4
Journal	Unknown Journal
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/S0015-0282(16)42190-4
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Prolonged elevation of luteinizing hormone (LH) after intranasal administration of an analog of LH releasing hormone",

abstract = "[D Leu 6, desGly NH 2 10] LH RH ethylamide, an analog of the luteinizing hormone releasing hormone (LH RH), was administered by intranasal spray or tube to 18 healthy men. A significant release of LH occurred within 15 minutes and was sustained for as long as 12 hours in what appeared to be a biphasic response. Both the spray and rhinyl tube were shown to be effective methods for releasing LH by intranasal administration of the LH RH analog.",

author = "D. Gonzalez-Barcena and Kastin, {A. J.} and Schalch, {D. S.} and Coy, {D. H.} and Schally, {A. V.}",

year = "1976",

doi = "10.1016/S0015-0282(16)42190-4",

language = "English (US)",

volume = "27",

pages = "1246--1249",

journal = "Scientific Computing and Instrumentation",

issn = "1078-8956",

publisher = "Springer Wien",

number = "11",

}

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T1 - Prolonged elevation of luteinizing hormone (LH) after intranasal administration of an analog of LH releasing hormone

AU - Gonzalez-Barcena, D.

AU - Kastin, A. J.

AU - Schalch, D. S.

AU - Coy, D. H.

AU - Schally, A. V.

PY - 1976

Y1 - 1976

N2 - [D Leu 6, desGly NH 2 10] LH RH ethylamide, an analog of the luteinizing hormone releasing hormone (LH RH), was administered by intranasal spray or tube to 18 healthy men. A significant release of LH occurred within 15 minutes and was sustained for as long as 12 hours in what appeared to be a biphasic response. Both the spray and rhinyl tube were shown to be effective methods for releasing LH by intranasal administration of the LH RH analog.

AB - [D Leu 6, desGly NH 2 10] LH RH ethylamide, an analog of the luteinizing hormone releasing hormone (LH RH), was administered by intranasal spray or tube to 18 healthy men. A significant release of LH occurred within 15 minutes and was sustained for as long as 12 hours in what appeared to be a biphasic response. Both the spray and rhinyl tube were shown to be effective methods for releasing LH by intranasal administration of the LH RH analog.

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AN - SCOPUS:0017202772

VL - 27

SP - 1246

EP - 1249

JO - Scientific Computing and Instrumentation

JF - Scientific Computing and Instrumentation

SN - 1078-8956

IS - 11

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