Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT)

Peter D. Reaven, Nicholas Emanuele, Thomas Moritz, Ronald Klein, Mathew Davis, Kathy Glander, William Duckworth, Carlos Abraira

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

OBJECTIVE - Increasing evidence suggests that macrovascular disease and retinopathy may be more closely linked than previously believed. We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC). RESEARCH DESIGN AND METHODS - The cross-sectional association between CAC and retinopathy was assessed on a Veteran Affairs Diabetes Trial subsample of 204 subjects with a mean duration of type 2 diabetes of 12.3 ± 8.3 years. RESULTS - Retinopathy was correlated with CAC (r = 0.19, P = 0.006). Median CAC increased across retinopathy categories: 197 in those with no retinopathy, 229 in those with microaneurysms only, 364 in those with mild nonproliferative diabetic retinopathy (NPDR), 300 in those with moderate to severe NPDR, and 981 in those with proliferative diabetic retinopathy (PDR). Stepwise multivariable linear regression analysis was performed to find a parsimonious subset of relevant risk factors to include along with PDR in predicting CAC. After adjustment for either this subset of standard factors (P = 0.047) or a more extensive panel of risk factors (P = 0.035), PDR was significantly associated with CAC. Moreover, using logistic regression, individuals with PDR were approximately sixfold more likely to have CAC >400 than those with no PDR, even after adjustment for other CVD risk factors. CONCLUSIONS - These data indicate an important relationship between retinopathy and extent of CAC and suggest the potential to identify and treat shared risk factors for these common micro- and macrovascular complications.

Original languageEnglish
Pages (from-to)952-957
Number of pages6
JournalDiabetes Care
Volume31
Issue number5
DOIs
StatePublished - May 1 2008

Fingerprint

Veterans
Diabetic Retinopathy
Type 2 Diabetes Mellitus
Coronary Vessels
Calcium
Coronary Artery Disease
Linear Models
Research Design
Logistic Models
Tomography
Regression Analysis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT). / Reaven, Peter D.; Emanuele, Nicholas; Moritz, Thomas; Klein, Ronald; Davis, Mathew; Glander, Kathy; Duckworth, William; Abraira, Carlos.

In: Diabetes Care, Vol. 31, No. 5, 01.05.2008, p. 952-957.

Research output: Contribution to journalArticle

Reaven, PD, Emanuele, N, Moritz, T, Klein, R, Davis, M, Glander, K, Duckworth, W & Abraira, C 2008, 'Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT)', Diabetes Care, vol. 31, no. 5, pp. 952-957. https://doi.org/10.2337/dc07-1926
Reaven, Peter D. ; Emanuele, Nicholas ; Moritz, Thomas ; Klein, Ronald ; Davis, Mathew ; Glander, Kathy ; Duckworth, William ; Abraira, Carlos. / Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT). In: Diabetes Care. 2008 ; Vol. 31, No. 5. pp. 952-957.
@article{26b43d16648843b3bd730cb988ab2ac8,
title = "Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT)",
abstract = "OBJECTIVE - Increasing evidence suggests that macrovascular disease and retinopathy may be more closely linked than previously believed. We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC). RESEARCH DESIGN AND METHODS - The cross-sectional association between CAC and retinopathy was assessed on a Veteran Affairs Diabetes Trial subsample of 204 subjects with a mean duration of type 2 diabetes of 12.3 ± 8.3 years. RESULTS - Retinopathy was correlated with CAC (r = 0.19, P = 0.006). Median CAC increased across retinopathy categories: 197 in those with no retinopathy, 229 in those with microaneurysms only, 364 in those with mild nonproliferative diabetic retinopathy (NPDR), 300 in those with moderate to severe NPDR, and 981 in those with proliferative diabetic retinopathy (PDR). Stepwise multivariable linear regression analysis was performed to find a parsimonious subset of relevant risk factors to include along with PDR in predicting CAC. After adjustment for either this subset of standard factors (P = 0.047) or a more extensive panel of risk factors (P = 0.035), PDR was significantly associated with CAC. Moreover, using logistic regression, individuals with PDR were approximately sixfold more likely to have CAC >400 than those with no PDR, even after adjustment for other CVD risk factors. CONCLUSIONS - These data indicate an important relationship between retinopathy and extent of CAC and suggest the potential to identify and treat shared risk factors for these common micro- and macrovascular complications.",
author = "Reaven, {Peter D.} and Nicholas Emanuele and Thomas Moritz and Ronald Klein and Mathew Davis and Kathy Glander and William Duckworth and Carlos Abraira",
year = "2008",
month = "5",
day = "1",
doi = "10.2337/dc07-1926",
language = "English",
volume = "31",
pages = "952--957",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "5",

}

TY - JOUR

T1 - Proliferative diabetic retinopathy in type 2 diabetes is related to coronary artery calcium in the veterans affairs diabetes trial (VADT)

AU - Reaven, Peter D.

AU - Emanuele, Nicholas

AU - Moritz, Thomas

AU - Klein, Ronald

AU - Davis, Mathew

AU - Glander, Kathy

AU - Duckworth, William

AU - Abraira, Carlos

PY - 2008/5/1

Y1 - 2008/5/1

N2 - OBJECTIVE - Increasing evidence suggests that macrovascular disease and retinopathy may be more closely linked than previously believed. We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC). RESEARCH DESIGN AND METHODS - The cross-sectional association between CAC and retinopathy was assessed on a Veteran Affairs Diabetes Trial subsample of 204 subjects with a mean duration of type 2 diabetes of 12.3 ± 8.3 years. RESULTS - Retinopathy was correlated with CAC (r = 0.19, P = 0.006). Median CAC increased across retinopathy categories: 197 in those with no retinopathy, 229 in those with microaneurysms only, 364 in those with mild nonproliferative diabetic retinopathy (NPDR), 300 in those with moderate to severe NPDR, and 981 in those with proliferative diabetic retinopathy (PDR). Stepwise multivariable linear regression analysis was performed to find a parsimonious subset of relevant risk factors to include along with PDR in predicting CAC. After adjustment for either this subset of standard factors (P = 0.047) or a more extensive panel of risk factors (P = 0.035), PDR was significantly associated with CAC. Moreover, using logistic regression, individuals with PDR were approximately sixfold more likely to have CAC >400 than those with no PDR, even after adjustment for other CVD risk factors. CONCLUSIONS - These data indicate an important relationship between retinopathy and extent of CAC and suggest the potential to identify and treat shared risk factors for these common micro- and macrovascular complications.

AB - OBJECTIVE - Increasing evidence suggests that macrovascular disease and retinopathy may be more closely linked than previously believed. We determined the relationship between retinopathy and coronary atherosclerosis as measured by computed tomography-detectable coronary artery calcium (CAC). RESEARCH DESIGN AND METHODS - The cross-sectional association between CAC and retinopathy was assessed on a Veteran Affairs Diabetes Trial subsample of 204 subjects with a mean duration of type 2 diabetes of 12.3 ± 8.3 years. RESULTS - Retinopathy was correlated with CAC (r = 0.19, P = 0.006). Median CAC increased across retinopathy categories: 197 in those with no retinopathy, 229 in those with microaneurysms only, 364 in those with mild nonproliferative diabetic retinopathy (NPDR), 300 in those with moderate to severe NPDR, and 981 in those with proliferative diabetic retinopathy (PDR). Stepwise multivariable linear regression analysis was performed to find a parsimonious subset of relevant risk factors to include along with PDR in predicting CAC. After adjustment for either this subset of standard factors (P = 0.047) or a more extensive panel of risk factors (P = 0.035), PDR was significantly associated with CAC. Moreover, using logistic regression, individuals with PDR were approximately sixfold more likely to have CAC >400 than those with no PDR, even after adjustment for other CVD risk factors. CONCLUSIONS - These data indicate an important relationship between retinopathy and extent of CAC and suggest the potential to identify and treat shared risk factors for these common micro- and macrovascular complications.

UR - http://www.scopus.com/inward/record.url?scp=48649101285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48649101285&partnerID=8YFLogxK

U2 - 10.2337/dc07-1926

DO - 10.2337/dc07-1926

M3 - Article

C2 - 18316393

AN - SCOPUS:48649101285

VL - 31

SP - 952

EP - 957

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 5

ER -