Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II)

C. J. Kovacs, Paul G Braunschweiger, L. L. Schenken, D. R. Burholt

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.

Original languageEnglish
Pages (from-to)286-294
Number of pages9
JournalBritish Journal of Cancer
Volume45
Issue number2
StatePublished - Jan 1 1982
Externally publishedYes

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Intestinal Mucosa
Cisplatin
Platinum
Kidney
Folic Acid
Epithelium
Cell Proliferation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kovacs, C. J., Braunschweiger, P. G., Schenken, L. L., & Burholt, D. R. (1982). Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). British Journal of Cancer, 45(2), 286-294.

Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). / Kovacs, C. J.; Braunschweiger, Paul G; Schenken, L. L.; Burholt, D. R.

In: British Journal of Cancer, Vol. 45, No. 2, 01.01.1982, p. 286-294.

Research output: Contribution to journalArticle

Kovacs, CJ, Braunschweiger, PG, Schenken, LL & Burholt, DR 1982, 'Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II)', British Journal of Cancer, vol. 45, no. 2, pp. 286-294.
Kovacs CJ, Braunschweiger PG, Schenken LL, Burholt DR. Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). British Journal of Cancer. 1982 Jan 1;45(2):286-294.
Kovacs, C. J. ; Braunschweiger, Paul G ; Schenken, L. L. ; Burholt, D. R. / Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). In: British Journal of Cancer. 1982 ; Vol. 45, No. 2. pp. 286-294.
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