Abstract
The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.
Original language | English (US) |
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Pages (from-to) | 286-294 |
Number of pages | 9 |
Journal | British Journal of Cancer |
Volume | 45 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1982 |
ASJC Scopus subject areas
- Oncology
- Cancer Research