Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II)

C. J. Kovacs, P. G. Braunschweiger, L. L. Schenken, D. R. Burholt

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.

Original languageEnglish (US)
Pages (from-to)286-294
Number of pages9
JournalBritish Journal of Cancer
Volume45
Issue number2
DOIs
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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