Abstract
The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.
| Original language | English |
|---|---|
| Pages (from-to) | 286-294 |
| Number of pages | 9 |
| Journal | British Journal of Cancer |
| Volume | 45 |
| Issue number | 2 |
| State | Published - Jan 1 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II). / Kovacs, C. J.; Braunschweiger, Paul G; Schenken, L. L.; Burholt, D. R.
In: British Journal of Cancer, Vol. 45, No. 2, 01.01.1982, p. 286-294.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proliferative defects in renal and intestinal epithelium after cis-dichlorodiammine platinum (II)
AU - Kovacs, C. J.
AU - Braunschweiger, Paul G
AU - Schenken, L. L.
AU - Burholt, D. R.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.
AB - The effects of cis-dichlorodiammine platinum II (DDP) on the intestinal mucosa and the kidney were studied after single and multiple treatments with intervals of 7-45 days. After a single treatment, the jejunal epithelium underwent a transient interruption of cell proliferation followed by a hyperplastic recovery and return to control proliferative rate on day 7. Subsequent treatments led to suboptimal recovery for all treatment intervals. In contrast, DDP induced a 6-fold increase in [3H]dT incorporation in the kidney by day 7 which remained high until day 21, and returned to near-control values by day 45. After a single DDP treatment, the 'recovery potential' of kidneys, measured by the proliferative response to folic-acid stress, demonstrated suboptimal proliferative reserve compartments for up to 45 days. The distinction between acute and delayed sensitivity to subsequent drug treatment was more apparent in the DDP-treated kidney than in the intestinal epithelium.
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M3 - Article
C2 - 7199350
AN - SCOPUS:0020056848
VL - 45
SP - 286
EP - 294
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 2
ER -