Abstract
Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catecholamines on prolactin release are physiological or pharmacological. Until such studies are completed and until the chemical nature and biological roles of other substances with PIF activity found in the hypothalamus are clarified, no conclusion as to the nature of the physiological inhibitor of prolactin release should be made.
| Original language | English |
|---|---|
| Pages (from-to) | 237-252 |
| Number of pages | 16 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 87 |
| State | Published - Jan 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Prolactin release inhibiting and stimulating factors in the hypothalamus. / Arimura, A.; Schally, Andrew V.
In: Advances in Experimental Medicine and Biology, Vol. 87, 01.01.1977, p. 237-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolactin release inhibiting and stimulating factors in the hypothalamus.
AU - Arimura, A.
AU - Schally, Andrew V
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catecholamines on prolactin release are physiological or pharmacological. Until such studies are completed and until the chemical nature and biological roles of other substances with PIF activity found in the hypothalamus are clarified, no conclusion as to the nature of the physiological inhibitor of prolactin release should be made.
AB - Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro. However, more work is needed to determine whether or not the effects of GABA or catecholamines on prolactin release are physiological or pharmacological. Until such studies are completed and until the chemical nature and biological roles of other substances with PIF activity found in the hypothalamus are clarified, no conclusion as to the nature of the physiological inhibitor of prolactin release should be made.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017326458&partnerID=8YFLogxK
M3 - Article
C2 - 19952
AN - SCOPUS:0017326458
VL - 87
SP - 237
EP - 252
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
SN - 0065-2598
ER -