Prolactin and the skin: A dermatological perspective on an ancient pleiotropic peptide hormone

Kerstin Foitzik, Ewan A. Langan, Ralf Paus

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

The polypeptide hormone prolactin (PRL) is best known as the pituitary modulator of lactation and reproduction. However, based on the almost ubiquitous distribution of PRL receptors (PRLR) and an ever-growing list of extrapituitary PRL-expressing tissues, a vast range of PRL actions "beyond the mammary horizon" has now been documented or claimed. For example, PRL modulates hair growth in domestic animals with seasonal hair growth changes ("PRL-pelage axis"). Given that the mammary gland is an epidermal derivative, it is not surprising that the pilosebaceous unit, another epidermal derivative, has also surfaced as a prominent, PRLR-expressing, nonclassical PRL target organ. Moreover, the fact that murine and human hair follicles even synthesize PRL strongly invites one to explore fully the dermatological dimensions of this multifunctional, cytokine-like neuroendocrine bioregulator, which remain insufficiently charted. After describing the relevant essentials of general PRL/PRLR biology, we summarize clinical observations that provide insights into how PRL may impact on the skin, and define important research frontiers and controversies in the quest to better characterize the complex role of PRL in human skin biology and pathology. Focusing on psoriasis, alopecia, and stress-related dermatoses, we then discuss the possible role of PRL/PRLR in cutaneous pathology, and identify potential therapeutic targets for the management of these skin disorders. We close by delineating major open questions at this emerging frontier of basic and clinical cutaneous neuroendocrinology, and argue that systematic exploration of the "PRL-skin connection" will fertilize the development of previously unreported neuroendocrinological strategies for managing selected skin disorders.

Original languageEnglish (US)
Pages (from-to)1071-1087
Number of pages17
JournalJournal of Investigative Dermatology
Volume129
Issue number5
DOIs
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Peptide Hormones
Prolactin
Skin
Prolactin Receptors
Hair
Pathology
Neuroendocrinology
Hair Follicle
Derivatives
Alopecia
Domestic Animals
Human Mammary Glands
Growth
Psoriasis
Lactation
Skin Diseases
Reproduction
Breast
Modulators
Cytokines

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Prolactin and the skin : A dermatological perspective on an ancient pleiotropic peptide hormone. / Foitzik, Kerstin; Langan, Ewan A.; Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 129, No. 5, 01.05.2009, p. 1071-1087.

Research output: Contribution to journalReview article

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