Prolactin: An emerging force along the cutaneous-endocrine axis

Ewan A. Langan, Kerstin Foitzik-Lau, Vincent Goffin, Yuval Ramot, R. Paus

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Prolactin (PRL), one of the most diverse regulators in mammalian biology, is produced in both human skin and hair follicles. Important advances in our understanding of the intracutaneous regulation and functions of PRL have recently been made using the serum-free skin and hair follicle organ culture technique. Given that human skin is the largest peripheral endocrine organ and a key interface between the endocrine, nervous and immune systems, a detailed understanding of PRL in the cutaneous context promises to have far-reaching implications beyond the skin. The current review presents a timely cutaneous perspective on the production, regulation and functions of PRL and summarizes the key questions facing extrapituitary PRL research in general and cutaneous PRL research in particular.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2010

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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