Prolactin: An emerging force along the cutaneous-endocrine axis

Ewan A. Langan, Kerstin Foitzik-Lau, Vincent Goffin, Yuval Ramot, Ralf Paus

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Prolactin (PRL), one of the most diverse regulators in mammalian biology, is produced in both human skin and hair follicles. Important advances in our understanding of the intracutaneous regulation and functions of PRL have recently been made using the serum-free skin and hair follicle organ culture technique. Given that human skin is the largest peripheral endocrine organ and a key interface between the endocrine, nervous and immune systems, a detailed understanding of PRL in the cutaneous context promises to have far-reaching implications beyond the skin. The current review presents a timely cutaneous perspective on the production, regulation and functions of PRL and summarizes the key questions facing extrapituitary PRL research in general and cutaneous PRL research in particular.

Original languageEnglish (US)
Pages (from-to)569-577
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number9
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Fingerprint

Prolactin
Skin
Hair Follicle
Endocrine System
Organ Culture Techniques
Research
Nervous System
Immune System
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Prolactin : An emerging force along the cutaneous-endocrine axis. / Langan, Ewan A.; Foitzik-Lau, Kerstin; Goffin, Vincent; Ramot, Yuval; Paus, Ralf.

In: Trends in Endocrinology and Metabolism, Vol. 21, No. 9, 01.09.2010, p. 569-577.

Research output: Contribution to journalReview article

Langan, Ewan A. ; Foitzik-Lau, Kerstin ; Goffin, Vincent ; Ramot, Yuval ; Paus, Ralf. / Prolactin : An emerging force along the cutaneous-endocrine axis. In: Trends in Endocrinology and Metabolism. 2010 ; Vol. 21, No. 9. pp. 569-577.
@article{7c3a4063b4fb4c4a9d7206f9d9916253,
title = "Prolactin: An emerging force along the cutaneous-endocrine axis",
abstract = "Prolactin (PRL), one of the most diverse regulators in mammalian biology, is produced in both human skin and hair follicles. Important advances in our understanding of the intracutaneous regulation and functions of PRL have recently been made using the serum-free skin and hair follicle organ culture technique. Given that human skin is the largest peripheral endocrine organ and a key interface between the endocrine, nervous and immune systems, a detailed understanding of PRL in the cutaneous context promises to have far-reaching implications beyond the skin. The current review presents a timely cutaneous perspective on the production, regulation and functions of PRL and summarizes the key questions facing extrapituitary PRL research in general and cutaneous PRL research in particular.",
author = "Langan, {Ewan A.} and Kerstin Foitzik-Lau and Vincent Goffin and Yuval Ramot and Ralf Paus",
year = "2010",
month = "9",
day = "1",
doi = "10.1016/j.tem.2010.06.001",
language = "English (US)",
volume = "21",
pages = "569--577",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Prolactin

T2 - An emerging force along the cutaneous-endocrine axis

AU - Langan, Ewan A.

AU - Foitzik-Lau, Kerstin

AU - Goffin, Vincent

AU - Ramot, Yuval

AU - Paus, Ralf

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Prolactin (PRL), one of the most diverse regulators in mammalian biology, is produced in both human skin and hair follicles. Important advances in our understanding of the intracutaneous regulation and functions of PRL have recently been made using the serum-free skin and hair follicle organ culture technique. Given that human skin is the largest peripheral endocrine organ and a key interface between the endocrine, nervous and immune systems, a detailed understanding of PRL in the cutaneous context promises to have far-reaching implications beyond the skin. The current review presents a timely cutaneous perspective on the production, regulation and functions of PRL and summarizes the key questions facing extrapituitary PRL research in general and cutaneous PRL research in particular.

AB - Prolactin (PRL), one of the most diverse regulators in mammalian biology, is produced in both human skin and hair follicles. Important advances in our understanding of the intracutaneous regulation and functions of PRL have recently been made using the serum-free skin and hair follicle organ culture technique. Given that human skin is the largest peripheral endocrine organ and a key interface between the endocrine, nervous and immune systems, a detailed understanding of PRL in the cutaneous context promises to have far-reaching implications beyond the skin. The current review presents a timely cutaneous perspective on the production, regulation and functions of PRL and summarizes the key questions facing extrapituitary PRL research in general and cutaneous PRL research in particular.

UR - http://www.scopus.com/inward/record.url?scp=77956185193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956185193&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2010.06.001

DO - 10.1016/j.tem.2010.06.001

M3 - Review article

C2 - 20598901

AN - SCOPUS:77956185193

VL - 21

SP - 569

EP - 577

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 9

ER -