Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases

Walter O’Dell, Cristiane Takita, Katherine Casey-Sawicki, Karen Daily, Coy D. Heldermon, Paul Okunieff

Research output: Contribution to journalArticle

Abstract

This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalBreast Journal
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • body imaging
  • breast cancer
  • metastases

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

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