Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases

Walter O’Dell, Cristiane Takita, Katherine Casey-Sawicki, Karen Daily, Coy D. Heldermon, Paul Okunieff

Research output: Contribution to journalArticle

Abstract

This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol.

Original languageEnglish (US)
JournalBreast Journal
DOIs
StateAccepted/In press - Jan 1 2018

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Breast Neoplasms
Neoplasm Metastasis
Aftercare
Survival
Radiosurgery
Disease-Free Survival
Therapeutics
Radiation
Clinical Studies

Keywords

  • body imaging
  • breast cancer
  • metastases

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

Cite this

Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases. / O’Dell, Walter; Takita, Cristiane; Casey-Sawicki, Katherine; Daily, Karen; Heldermon, Coy D.; Okunieff, Paul.

In: Breast Journal, 01.01.2018.

Research output: Contribution to journalArticle

O’Dell, Walter ; Takita, Cristiane ; Casey-Sawicki, Katherine ; Daily, Karen ; Heldermon, Coy D. ; Okunieff, Paul. / Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases. In: Breast Journal. 2018.
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