Progressive multifocal leukoencephalopathy in HIV-1-infected children

J. R. Berger, G. Scott, J. Albrecht, A. L. Belman, C. Tornatore, E. O. Major

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Objective: To describe the clinical and pathologic features of two HIV-1-infected children with progressive multifocal leukoencephalopathy (PML). Design: Case report. Setting: University-affiliated, public-health trust hospital. Methods: Two HIV-1-infected children with PML are described. A 13-year-old girl, presumed to be congenially infected with HIV-1, presented with dysarthria and paresthesias of the tongue and chin that evolved rapidly to dementia, muteness and severe spastic quadriparesis. The other patient, a 10-year-old boy who developed HIV-1 infection from a blood transfusion at the age of 3 years, presented with a facial palsy with subsequent development of right hemiparesis and aphasia. Results: Brain biopsy in the first child and autopsy in the second confirmed the diagnosis of PML. In both patients, the CD4 T-lymphocyte count was < 100 x 106/l at the time of neurological presentation. Conclusion: Despite seroepidemiological studies suggesting that the majority of individuals are infected with JC virus during childhood, PML is rare in children with impaired cell-mediated immunity. Our patients illustrate that PML is among the neurological complications of HIV-1 infection in children.

Original languageEnglish (US)
Pages (from-to)837-841
Number of pages5
JournalAIDS
Volume6
Issue number8
DOIs
StatePublished - 1992

Keywords

  • AIDS
  • Children
  • HIV-1
  • JC virus
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Progressive multifocal leukoencephalopathy in HIV-1-infected children'. Together they form a unique fingerprint.

  • Cite this

    Berger, J. R., Scott, G., Albrecht, J., Belman, A. L., Tornatore, C., & Major, E. O. (1992). Progressive multifocal leukoencephalopathy in HIV-1-infected children. AIDS, 6(8), 837-841. https://doi.org/10.1097/00002030-199208000-00012