Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: Neuroimaging with clinical and pathologic correlation

M. L.H. Whiteman, M. J.D. Post, J. R. Berger, L. G. Tate, M. D. Bell, L. P. Limonte

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

The authors investigated the spectrum of radiologic findings in a large saries (n = 47) of patients seropositive to human immunodeficiency virus (HIV) 1 and with pathologically proved progressive multifocal leukoencephalopathy, to determine the characteristic imaging pattern of the disease. Thirty-six computed tomographic (CT) scans and 29 magnetic resonance (MR) imaging studies obtained in the 47 patients were retrospectively reviewed and correlated with pathologic and clinical findings. Contrast agents were used in 32 CT procedures and 13 MR imaging studies. Lesions typically were hypoattenuating on CT scans and were characterized by areas of increased signal intensity without mass effect on dualecho MR images. Lesions most often involved periventricular and subcortical white matter in parietooccipital or frontal lobes. Fifteen patients had posterior fossa lesions, and disease limited to the posterior fossa in Lesions were also in the corpus callsum (seven patients), thalamus (eight patients), and basal ganglia (seven patients). In comparison with CT, MR imaging demonstrated greater sensitivity for the extent and number of lesions.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalRadiology
Volume187
Issue number1
DOIs
StatePublished - 1993

Keywords

  • Acquired immunodeficiency syndrome (AIDS), 10.298
  • Brain, CT, 10.1211
  • Brain, infection, 10.298, 13.8721, 14.8721

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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