Progressive hyperpigmentation: Case report with a clinical, histological, and ultastructural investigation

C. M. Betts, F. Bardazzi, P. A. Fanti, Antonella Tosti, C. Varotti

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A clinical, histological and ultrastructural study of a 38-year-old woman with generalized progressive hyperpigmentation is reported. Hyperpigmentation started in early infancy, progressed during childhood and has increased to a dark bronze-brown color with 'mottling' in the last 8 years. Histology and electron microscopy revealed epidermal hypermelanosis and 'negroid' distribution of melanosomes in keratinocytes. In our family, autosomal dominant phenotype transmission with 'variable expression' is suggested. The literature on the entity has been reviewed. This case is another rare example of familial progressive hyperpigmentation.

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalDermatology
Volume189
Issue number4
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Hyperpigmentation
Melanosomes
Keratinocytes
Histology
Electron Microscopy
Color
Phenotype

Keywords

  • Genodermatosis
  • Hyperpigmentation
  • Melanosomes
  • Ultrastructure

ASJC Scopus subject areas

  • Dermatology

Cite this

Progressive hyperpigmentation : Case report with a clinical, histological, and ultastructural investigation. / Betts, C. M.; Bardazzi, F.; Fanti, P. A.; Tosti, Antonella; Varotti, C.

In: Dermatology, Vol. 189, No. 4, 01.01.1994, p. 384-391.

Research output: Contribution to journalArticle

Betts, CM, Bardazzi, F, Fanti, PA, Tosti, A & Varotti, C 1994, 'Progressive hyperpigmentation: Case report with a clinical, histological, and ultastructural investigation', Dermatology, vol. 189, no. 4, pp. 384-391.
Betts, C. M. ; Bardazzi, F. ; Fanti, P. A. ; Tosti, Antonella ; Varotti, C. / Progressive hyperpigmentation : Case report with a clinical, histological, and ultastructural investigation. In: Dermatology. 1994 ; Vol. 189, No. 4. pp. 384-391.
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