Progression to AIDS in the absence of a gene for vpr or vpx

J. S. Gibbs, A. A. Lackner, S. M. Lang, M. A. Simon, P. K. Sehgal, M. D. Daniel, Ronald Charles Desrosiers

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Rhesus monkeys (Macaca mulatta) were experimentally infected with strains of simian immunodeficiency virus (SIV) derived from SIV(mac)239 lacking vpr, vpx, nr both vpr and vpx genes. These auxiliary genes are not required for virus replication in cultured cells but are consistently conserved within the SiV(mac)/human immunodeficiency virus type 2/SIV(sm) group of primate lentiviruses. All four rhesus monkeys infected with the vpr deletion mutant showed an early spike in plasma antigenemia, maintained high virus burdens, exhibited declines in CD4+ lymphocyte concentrations, and had significant changes in lymph node morphology, and two have died to date with AIDS. The behavior of the vpr deletion mutant was indistinguishable from that of the parental, wild-type virus. Rhesus monkeys infected with the vpx deletion mutant showed lower levels of plasma antigenemia, lower virus burdens, and delayed declines in CD4+ lymphocyte concentrations but nonetheless progressed with AIDS tn a terminal stage. The vpr + vpx double mutant was severely attenuated, with much lower virus burdens and no evidence of disease progression. These and other results indicate that vpr provides only a slight facilitating advantage for wild-type SIV(mac) replication in vivo. Thus, progression to AIDS and death can occur in the absence of a gene for vpr or vpx.

Original languageEnglish (US)
Pages (from-to)2378-2383
Number of pages6
JournalJournal of Virology
Volume69
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

vpr Genes
Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca mulatta
Acquired Immunodeficiency Syndrome
viral load
Viruses
mutants
Virus Replication
lymphocytes
genes
Primate Lentiviruses
Human immunodeficiency virus 2
Lymphocytes
Lentivirus
HIV-2
virus replication
disease course
cultured cells
lymph nodes

ASJC Scopus subject areas

  • Immunology

Cite this

Gibbs, J. S., Lackner, A. A., Lang, S. M., Simon, M. A., Sehgal, P. K., Daniel, M. D., & Desrosiers, R. C. (1995). Progression to AIDS in the absence of a gene for vpr or vpx. Journal of Virology, 69(4), 2378-2383.

Progression to AIDS in the absence of a gene for vpr or vpx. / Gibbs, J. S.; Lackner, A. A.; Lang, S. M.; Simon, M. A.; Sehgal, P. K.; Daniel, M. D.; Desrosiers, Ronald Charles.

In: Journal of Virology, Vol. 69, No. 4, 1995, p. 2378-2383.

Research output: Contribution to journalArticle

Gibbs, JS, Lackner, AA, Lang, SM, Simon, MA, Sehgal, PK, Daniel, MD & Desrosiers, RC 1995, 'Progression to AIDS in the absence of a gene for vpr or vpx', Journal of Virology, vol. 69, no. 4, pp. 2378-2383.
Gibbs JS, Lackner AA, Lang SM, Simon MA, Sehgal PK, Daniel MD et al. Progression to AIDS in the absence of a gene for vpr or vpx. Journal of Virology. 1995;69(4):2378-2383.
Gibbs, J. S. ; Lackner, A. A. ; Lang, S. M. ; Simon, M. A. ; Sehgal, P. K. ; Daniel, M. D. ; Desrosiers, Ronald Charles. / Progression to AIDS in the absence of a gene for vpr or vpx. In: Journal of Virology. 1995 ; Vol. 69, No. 4. pp. 2378-2383.
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