Progression to AIDS, a clinical AIDS condition and mortality: Psychosocial and physiological predictors

J. Leserman, J. M. Petitto, H. Gu, B. N. Gaynes, J. Barroso, R. N. Golden, D. O. Perkins, J. D. Folds, D. L. Evans

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Background. The primary aim of this study is to examine prospectively the association of stressful life events, social support, depressive symptoms, anger, serum cortisol and lymphocyte subsets with changes in multiple measures of human immunodeficiency virus (HIV) disease progression. Methods. Ninety-six HIV-infected gay men without symptoms or anti-retroviral medication use at baseline were studied every 6 months for up to 9 years. Disease progression was defined in three ways using the Centers for Disease Control (CDC) classifications (e.g. AIDS, clinical AIDS condition and mortality). Cox regression models with time-dependent covariates were used, adjusting for control variables (e.g. race, age, baseline, CD4 T cells and viral load, number of anti-retroviral medications). Results. Higher cumulative average stressful life events and lower cumulative average social support predicted faster progression to both the CDC AIDS classification and a clinical AIDS condition. Higher anger scores and CD8 T cells were associated with faster progression to AIDS, and depressive symptoms were associated with faster development of an AIDS clinical condition. Higher levels of serum cortisol predicted all three measures of disease progression. Conclusions. These results suggest that stressful life events, dysphoric mood and limited social support are associated with more rapid clinical progression in HIV infection, with serum cortisol also exerting an independent effect on disease progression.

Original languageEnglish (US)
Pages (from-to)1059-1073
Number of pages15
JournalPsychological Medicine
Volume32
Issue number6
DOIs
StatePublished - Aug 2002
Externally publishedYes

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Acquired Immunodeficiency Syndrome
Disease Progression
Mortality
Social Support
Hydrocortisone
Anger
HIV
Virus Diseases
Centers for Disease Control and Prevention (U.S.)
Serum
Depression
T-Lymphocytes
Lymphocyte Subsets
Viral Load
Proportional Hazards Models

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Leserman, J., Petitto, J. M., Gu, H., Gaynes, B. N., Barroso, J., Golden, R. N., ... Evans, D. L. (2002). Progression to AIDS, a clinical AIDS condition and mortality: Psychosocial and physiological predictors. Psychological Medicine, 32(6), 1059-1073. https://doi.org/10.1017/S0033291702005949

Progression to AIDS, a clinical AIDS condition and mortality : Psychosocial and physiological predictors. / Leserman, J.; Petitto, J. M.; Gu, H.; Gaynes, B. N.; Barroso, J.; Golden, R. N.; Perkins, D. O.; Folds, J. D.; Evans, D. L.

In: Psychological Medicine, Vol. 32, No. 6, 08.2002, p. 1059-1073.

Research output: Contribution to journalArticle

Leserman, J, Petitto, JM, Gu, H, Gaynes, BN, Barroso, J, Golden, RN, Perkins, DO, Folds, JD & Evans, DL 2002, 'Progression to AIDS, a clinical AIDS condition and mortality: Psychosocial and physiological predictors', Psychological Medicine, vol. 32, no. 6, pp. 1059-1073. https://doi.org/10.1017/S0033291702005949
Leserman, J. ; Petitto, J. M. ; Gu, H. ; Gaynes, B. N. ; Barroso, J. ; Golden, R. N. ; Perkins, D. O. ; Folds, J. D. ; Evans, D. L. / Progression to AIDS, a clinical AIDS condition and mortality : Psychosocial and physiological predictors. In: Psychological Medicine. 2002 ; Vol. 32, No. 6. pp. 1059-1073.
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