Progression of transsynaptic retinal degeneration with spectral-domain optical coherence tomography

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7 Scopus citations


Purpose To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral-domain optical coherence tomography (SD-OCT). Observations A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the macula, ganglion cell layer (GCC), and retinal nerve fiber layer. Transsynaptic retinal degeneration progressed over this time. Conclusions and importance Retrograde transsynaptic retinal degeneration may occur in patients with homonymous visual field loss caused by post-geniculate neurologic disease. This is best detected as homonymous thinning of the retina, corresponding to the pattern of visual field loss, using SD-OCT of the GCC and macula. The retinal changes occur at a variable time following the onset of neurologic disease.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalAmerican Journal of Ophthalmology Case Reports
StatePublished - Apr 1 2017


  • Ganglion cell complex
  • Retinal nerve fiber layer
  • Spectral-domain optical coherence tomography
  • Transsynaptic degeneration

ASJC Scopus subject areas

  • Ophthalmology


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