Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

on behalf of the PROG-IMT study group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

Original languageEnglish (US)
JournalEuropean Journal of Preventive Cardiology
DOIs
StateAccepted/In press - Jan 1 2019

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Vascular Diseases
Cardiovascular Diseases
Blood Pressure
LDL Cholesterol
HDL Cholesterol
Confidence Intervals
Meta-Analysis
Cholesterol
Carotid Intima-Media Thickness
Blood Vessels
Cohort Studies
Stroke
Odds Ratio
Myocardial Infarction
Prospective Studies

Keywords

  • CVD biomarker
  • risk factor progression
  • Risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{62f7f85cb53e4761a65321422f0c97f3,
title = "Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium",
abstract = "Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95{\%} confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95{\%} CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95{\%} CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95{\%} CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.",
keywords = "CVD biomarker, risk factor progression, Risk factors",
author = "{on behalf of the PROG-IMT study group} and Martin Bahls and Lorenz, {Matthias W.} and Marcus D{\"o}rr and Lu Gao and Kazuo Kitagawa and Tuomainen, {Tomi Pekka} and Stefan Agewall and Gerald Berenson and Catapano, {Alberico L.} and Norata, {Giuseppe D.} and Bots, {Michiel L.} and {van Gilst}, Wiek and Asselbergs, {Folkert W.} and Brouwers, {Frank P.} and Heiko Uthoff and Dirk Sander and Holger Poppert and {Hecht Olsen}, Michael and Empana, {Jean Philippe} and Ulf Schminke and Damiano Baldassarre and Fabrizio Veglia and Franco, {Oscar H.} and Maryam Kavousi and {de Groot}, Eric and Mathiesen, {Ellisiv B.} and Liliana Grigore and Polak, {Joseph F.} and Tatjana Rundek and Stehouwer, {Coen D.A.} and Skilton, {Michael R.} and Hatzitolios, {Apostolos I.} and Christos Savopoulos and George Ntaios and Matthieu Plichart and Stela McLachlan and Lars Lind and Peter Willeit and Helmuth Steinmetz and Moise Desvarieux and Ikram, {M. Arfan} and Johnsen, {Stein Harald} and Caroline Schmidt and Johann Willeit and Pierre Ducimetiere and Price, {Jackie F.} and G{\"o}ran Bergstr{\"o}m and Jussi Kauhanen and Stefan Kiechl and Sacco, {Ralph L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1177/2047487319877078",
language = "English (US)",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications Ltd",

}

TY - JOUR

T1 - Progression of conventional cardiovascular risk factors and vascular disease risk in individuals

T2 - insights from the PROG-IMT consortium

AU - on behalf of the PROG-IMT study group

AU - Bahls, Martin

AU - Lorenz, Matthias W.

AU - Dörr, Marcus

AU - Gao, Lu

AU - Kitagawa, Kazuo

AU - Tuomainen, Tomi Pekka

AU - Agewall, Stefan

AU - Berenson, Gerald

AU - Catapano, Alberico L.

AU - Norata, Giuseppe D.

AU - Bots, Michiel L.

AU - van Gilst, Wiek

AU - Asselbergs, Folkert W.

AU - Brouwers, Frank P.

AU - Uthoff, Heiko

AU - Sander, Dirk

AU - Poppert, Holger

AU - Hecht Olsen, Michael

AU - Empana, Jean Philippe

AU - Schminke, Ulf

AU - Baldassarre, Damiano

AU - Veglia, Fabrizio

AU - Franco, Oscar H.

AU - Kavousi, Maryam

AU - de Groot, Eric

AU - Mathiesen, Ellisiv B.

AU - Grigore, Liliana

AU - Polak, Joseph F.

AU - Rundek, Tatjana

AU - Stehouwer, Coen D.A.

AU - Skilton, Michael R.

AU - Hatzitolios, Apostolos I.

AU - Savopoulos, Christos

AU - Ntaios, George

AU - Plichart, Matthieu

AU - McLachlan, Stela

AU - Lind, Lars

AU - Willeit, Peter

AU - Steinmetz, Helmuth

AU - Desvarieux, Moise

AU - Ikram, M. Arfan

AU - Johnsen, Stein Harald

AU - Schmidt, Caroline

AU - Willeit, Johann

AU - Ducimetiere, Pierre

AU - Price, Jackie F.

AU - Bergström, Göran

AU - Kauhanen, Jussi

AU - Kiechl, Stefan

AU - Sacco, Ralph L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

AB - Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in individuals with the risk of future clinical endpoints.

KW - CVD biomarker

KW - risk factor progression

KW - Risk factors

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U2 - 10.1177/2047487319877078

DO - 10.1177/2047487319877078

M3 - Article

C2 - 31619084

AN - SCOPUS:85074338122

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

ER -