Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2

the MacTel Study Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm 2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.

Original languageEnglish (US)
JournalActa Ophthalmologica
DOIs
StatePublished - Jan 1 2019

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Telangiectasis
Visual Acuity
Cohort Studies
Clinical Trials
Growth

Keywords

  • ellipsoid zone
  • en face image
  • MacTel
  • macular telangiectasia type 2
  • OCT

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2. / the MacTel Study Group.

In: Acta Ophthalmologica, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Progression characteristics of ellipsoid zone loss in macular telangiectasia type 2",
abstract = "Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm 2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.",
keywords = "ellipsoid zone, en face image, MacTel, macular telangiectasia type 2, OCT",
author = "{the MacTel Study Group} and Daniel Pauleikhoff and Roberto Bonelli and Dubis, {Adam M.} and Frederic Gunnemann and Kai Rothaus and {Charbel Issa}, Peter and Heeren, {Tjebo F.C.} and Tunde Peto and Clemons, {Traci E.} and Chew, {Emily Y.} and Bird, {Alan C.} and Sallo, {Ferenc B.} and Sophie Bakri and Bernstein, {Paul S.} and Barbara Blodi and Alexander Brucker and Felicitas Bucher and Mina Chung and Grant Comer and Ian Constable and Michael Cooney and Diana Do and Jacque Duncan and Catherine Egan and Elman, {Michael J.} and Amani Fawzi and Martin Friedlander and Alain Gaudric and Gillies, {Mark C.} and Roger Goldberg and Googe, {Joseph M.} and Robyn Guymer and Patrick Higgins and Frank Holz and Odette Houghton and Hoyng, {Carel B.} and Hubschman, {Jean Pierre} and Chirag Jhaveri and Arshad Khanani and David Lally and Cecilia Lee and Michael Lee and Miller, {Joan W.} and Daniel Miller and Joseph Moisseiev and Robert Murphy and Raja Narayanan and Sandeep Randhawa and Raphaelian, {Paul V.} and Rosenfeld, {Philip J}",
year = "2019",
month = "1",
day = "1",
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language = "English (US)",
journal = "Acta Ophthalmologica",
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AU - the MacTel Study Group

AU - Pauleikhoff, Daniel

AU - Bonelli, Roberto

AU - Dubis, Adam M.

AU - Gunnemann, Frederic

AU - Rothaus, Kai

AU - Charbel Issa, Peter

AU - Heeren, Tjebo F.C.

AU - Peto, Tunde

AU - Clemons, Traci E.

AU - Chew, Emily Y.

AU - Bird, Alan C.

AU - Sallo, Ferenc B.

AU - Bakri, Sophie

AU - Bernstein, Paul S.

AU - Blodi, Barbara

AU - Brucker, Alexander

AU - Bucher, Felicitas

AU - Chung, Mina

AU - Comer, Grant

AU - Constable, Ian

AU - Cooney, Michael

AU - Do, Diana

AU - Duncan, Jacque

AU - Egan, Catherine

AU - Elman, Michael J.

AU - Fawzi, Amani

AU - Friedlander, Martin

AU - Gaudric, Alain

AU - Gillies, Mark C.

AU - Goldberg, Roger

AU - Googe, Joseph M.

AU - Guymer, Robyn

AU - Higgins, Patrick

AU - Holz, Frank

AU - Houghton, Odette

AU - Hoyng, Carel B.

AU - Hubschman, Jean Pierre

AU - Jhaveri, Chirag

AU - Khanani, Arshad

AU - Lally, David

AU - Lee, Cecilia

AU - Lee, Michael

AU - Miller, Joan W.

AU - Miller, Daniel

AU - Moisseiev, Joseph

AU - Murphy, Robert

AU - Narayanan, Raja

AU - Randhawa, Sandeep

AU - Raphaelian, Paul V.

AU - Rosenfeld, Philip J

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm 2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.

AB - Purpose: To investigate the progression characteristics of ellipsoid zone (EZ) loss in eyes with macular telangiectasia type 2 (MacTel) as reflected by area and linear measurements, and their relevance for visual acuity. Methods: Participants were selected from the MacTel Study cohort. Linear and area measurements of EZ loss were performed in Spectral-Domain Optical Coherence Tomograph (SD-OCT) volume scans. Progression characteristics and correlations between linear and area measurements were analysed using linear mixed effects models. Results: A total of 134 eyes of 70 patients were included (85 eyes with follow-up, mean 4.7 years, range: 1.4–8 years). Ellipsoid zone (EZ) loss significantly progressed at a mean annual increment of 0.057 mm 2 (p = 0.005). The progression rate was non-linear and interacted significantly with initial EZ lesion size indicating an exponential growth before reaching a plateau. There was a strong heterogeneity in area sizes between fellow eyes. EZ break length had a significant linear effect on EZ break area (b = 1.06, p < 0.001) and could predict it. The location of the EZ break had a significant impact on visual acuity. Conclusion: Ellipsoid zone (EZ) loss in MacTel has a non-linear progression characteristic, and its rate depends on area size at baseline, which must be taken into account at sample selection in clinical trials. Our results show a good correlation of linear and area measures of EZ loss and a segregation of best-corrected visual acuity by EZ location, which may help routine clinical practice.

KW - ellipsoid zone

KW - en face image

KW - MacTel

KW - macular telangiectasia type 2

KW - OCT

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DO - 10.1111/aos.14110

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JO - Acta Ophthalmologica

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SN - 1755-375X

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