Progress against follicular lymphoma

Jonathan H Schatz, Elisa Oricchio, Soham D. Puvvada, H. Guido Wendel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose of Review: To share the recent progress in research and new therapies against follicular lymphoma and highlight the exciting opportunities to improve the treatment of follicular lymphoma. RECENT FINDINGS: Follicular lymphoma has been somewhat neglected by the research community, but recent genomic studies have identified key genetic lesions in follicular lymphoma. In addition, a new murine model is available to explore the function of these lesions in the development, progression, and treatment of follicular lymphoma. Moreover, new small-molecule inhibitors are now available that target key pathways in follicular lymphoma including B-cell receptor signaling and histone modifiers. SUMMARY: Follicular lymphoma is a very common and still incurable form of lymphoma. However, recent genomic and in-vivo biological studies are beginning to unveil the molecular drivers of follicular lymphoma. This coincides with the development of effective small-molecule inhibitors against key targets. Together these developments suggest that we are at a long overdue watershed moment in the treatment of follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalCurrent Opinion in Hematology
Volume20
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

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Keywords

  • Experimental models
  • Follicular lymphoma
  • Genomics
  • Pathogenesis
  • Therapy

ASJC Scopus subject areas

  • Hematology

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