Programmed cell death in fission yeast

Luis Rodriguez-Menocal, Gennaro D'Urso

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations


Recently a metacaspase, encoded by YCA1, has been implicated in a primitive form of apoptosis or programmed cell death in yeast. Previously it had been shown that over-expression of mammalian pro-apoptotic proteins can induce cell death in yeast, but the mechanism of how cell death occurred was not clearly established. More recently, it has been shown that DNA or oxidative damage, or other cell cycle blocks, can result in cell death that mimics apoptosis in higher cells. Also, in fission yeast deletion of genes required for triacylglycerol synthesis leads to cell death and expression of apoptotic markers. A metacaspase sharing greater than 40% identity to budding yeast Yca1 has been identified in fission yeast, however, its role in programmed cell death is not yet known. Analysis of the genetic pathways that influence cell death in yeast may provide insights into the mechanisms of apoptosis in all eukaryotic organisms.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalFEMS Yeast Research
Issue number2
StatePublished - Nov 2004
EventApoptosis-like Cell Death Programs in Yeasts - Smolenice, Slovakia
Duration: Sep 1 2003Sep 1 2003


  • Apoptosis
  • Cell cycle
  • Fission yeast

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Infectious Diseases


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