Prognostic value of bc1 10 rearrangement in diffuse large B-cell lymphoma

C. Kawasaki, K. Ohshima, H. Muta, K. Muta, V. Deyev, E. R. Podack, M. Kikuchi

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The role of bcl 10, a recently cloned apoptosis-associated gene, in diffuse large B-cell lymphoma (DLBL) is unknown. Here we determined the role of bcl 10 gene rearrangement on prognosis. Bcl 10 rearrangement was examined by Southern blot. Bcl 10 rearrangement was detected in 20 of 137 (14.6%) samples of DLBL. The frequency of bcl 10 rearrangement was higher in extranodal (eight of 38 cases, 21%) than in nodal (12 of 99, 12%) DLBL. The survival rate in patients with bcl 10 rearrangement tended to be better than in those with germ-line bcl 10, albeit statistically insignificant probably due to the small population sample. The superior prognosis in patients with bcl 10 rearrangement might be due to bcl 10-induced enhanced apoptosis.

Original languageEnglish (US)
Pages (from-to)823-826
Number of pages4
JournalLeukemia and Lymphoma
Volume43
Issue number4
DOIs
StatePublished - May 4 2002

Keywords

  • Bcl 10
  • Caspase recruitment domain
  • Diffuse large B-cell lymphoma
  • Mucosa-associated lymphoid tissue

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Kawasaki, C., Ohshima, K., Muta, H., Muta, K., Deyev, V., Podack, E. R., & Kikuchi, M. (2002). Prognostic value of bc1 10 rearrangement in diffuse large B-cell lymphoma. Leukemia and Lymphoma, 43(4), 823-826. https://doi.org/10.1080/10428190290016953