Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix

L. A. King, T. Tase, L. B. Twiggs, T. Okagaki, J. E. Savage, L. L. Adcock, K. A. Prem, L. F. Carson

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Cases of invasive carcinoma of the uterine cervix were analyzed to determine whether the presence or absence of human papillomavirus (HPV) DNA in the neoplasms was a contributing factor to their outcome. The presence of HPV DNA was evaluated using in situ hybridization on formalin-fixed, paraffin-embedded tissue sections. Eighty-five patients with cervical carcinoma who had been surgically evaluated were included in the study. Data from these patients was analyzed retrospectively to determine survival, recurrence, presence of nodal metastases, tumor grade, mode of therapy, peritoneal fluid cytologic results, and age in relation to presence or absence of HPV DNA. No significant statistical differences were found between the HPV-16-positive, HPV-18-positive, and HPV DNA-negative patients.

Original languageEnglish
Pages (from-to)897-900
Number of pages4
JournalCancer
Volume63
Issue number5
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Cervix Uteri
Carcinoma
DNA
Neoplasm DNA
Human papillomavirus 18
Human papillomavirus 16
Ascitic Fluid
Paraffin
Formaldehyde
In Situ Hybridization
Neoplasm Metastasis
Recurrence
Survival
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

King, L. A., Tase, T., Twiggs, L. B., Okagaki, T., Savage, J. E., Adcock, L. L., ... Carson, L. F. (1989). Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. Cancer, 63(5), 897-900.

Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. / King, L. A.; Tase, T.; Twiggs, L. B.; Okagaki, T.; Savage, J. E.; Adcock, L. L.; Prem, K. A.; Carson, L. F.

In: Cancer, Vol. 63, No. 5, 01.01.1989, p. 897-900.

Research output: Contribution to journalArticle

King, LA, Tase, T, Twiggs, LB, Okagaki, T, Savage, JE, Adcock, LL, Prem, KA & Carson, LF 1989, 'Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix', Cancer, vol. 63, no. 5, pp. 897-900.
King LA, Tase T, Twiggs LB, Okagaki T, Savage JE, Adcock LL et al. Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. Cancer. 1989 Jan 1;63(5):897-900.
King, L. A. ; Tase, T. ; Twiggs, L. B. ; Okagaki, T. ; Savage, J. E. ; Adcock, L. L. ; Prem, K. A. ; Carson, L. F. / Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix. In: Cancer. 1989 ; Vol. 63, No. 5. pp. 897-900.
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