Prognostic significance of steroid receptors measured in primary metastatic and recurrent endometrial carcinoma

Gholamreza Borazjani, Leo B. Twiggs, Benjamin S. Leung, Konald A. Prem, Leon L. Adcock, Linda F. Carson

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Forty-two cases of recurrent and 14 cases of advanced clinical stage (III and IV) endometrial carcinoma are presented, in which progesterone and estrogen receptors from the metastatic sites were measured. Mean survival time (time from recurrence or, in advanced stages, from the time of diagnosis to death or last follow-up), mean total survival time (time from diagnosis to death or last follow-up), and mean time to recurrence (time from diagnosis of primary tumor to the time of recurrence) were positively correlated with positive progesterone and estrogen receptor status and with histologic grade of tumor. No correlation was found with age, clinical stage, depth of myometrial invasion, or site of metastasis. However, when multiple variables were considered with the Cox regression model, the combination most highly correlated with survival included progesterone receptor, grade of tumor, and site of metastasis (pelvis vs. other sites). All differences were statistically significant (p < 0.05). We conclude that measurement of progesterone and estrogen receptors in metastatic or recurrent endometrial tumors may be used as an additional prognostic variable.

Original languageEnglish (US)
Pages (from-to)1253-1257
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume161
Issue number5
DOIs
StatePublished - Nov 1989

Keywords

  • prognosis
  • Recurrent endometrial cancer
  • steroid receptor

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

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