Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas

Yasser M. El-Gohary, Ghada Metwally, Reda S. Saad, Morton J. Robinson, Thomas Mesko, Robert J. Poppiti

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

We studied tumor lymphatic and vascular densities and lymphovascular invasion (LVI) as prognostic markers in 48 cases of invasive breast cancer treated with partial or total mastectomy and lymph node dissection. All cases were immunostained with D2-40 and CD31. Positively stained microvessels were counted in densely vascular/lymphatic foci (hot spots) at ×400. The mean ± SD peritumoral lymphatic microvessel density (LMD) was significantly higher than intratumoral LMD (9 ± 7 vs 4 ± 6; P < .01). There was a positive correlation of D2-40 LMD (peritumoral and intratumoral) and CD31 microvessel density counts with lymph node metastasis (r = 0.35, 0.5, and 0.38), nuclear grade (r = 0.36, 0.28, and 0.3), and stage (r = 0.42, 0.56, and 0.49), respectively. Peritumoral and intratumoral D2-40 LMD correlated significantly with the presence of angiolymphatic invasion (detected by D2-40; r = 0.54 and 0.54, respectively). D2-40 detected more LVI than H&E- and CD31-detectable vascular invasion (18/48, 5/48, 11/48, respectively). Increased D2-40 detected LVI, and high CD31 microvessel counts showed significant adverse effect on survival status.

Original languageEnglish
Pages (from-to)578-586
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume129
Issue number4
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Fingerprint

Lymphatic Vessels
Microvessels
Blood Vessels
Breast Neoplasms
Simple Mastectomy
Segmental Mastectomy
Lymph Node Excision
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Blood
  • Density
  • Invasive breast carcinoma
  • Lymphatics
  • Microvessels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas. / El-Gohary, Yasser M.; Metwally, Ghada; Saad, Reda S.; Robinson, Morton J.; Mesko, Thomas; Poppiti, Robert J.

In: American Journal of Clinical Pathology, Vol. 129, No. 4, 01.04.2008, p. 578-586.

Research output: Contribution to journalArticle

El-Gohary, Yasser M. ; Metwally, Ghada ; Saad, Reda S. ; Robinson, Morton J. ; Mesko, Thomas ; Poppiti, Robert J. / Prognostic significance of intratumoral and peritumoral lymphatic density and blood vessel density in invasive breast carcinomas. In: American Journal of Clinical Pathology. 2008 ; Vol. 129, No. 4. pp. 578-586.
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