Prognostic significance of DNA aneuploidy in diffuse malignant mesothelioma

Hiroshi Isobe, Kasi S. Sridhar, Raul Doria, Felicia Cohen, William A. Raub, Mario Saldana, Awtar Krishan

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

DNA ploidy of pepsin digested preparations of 48 paraffin-embedded specimens from 19 patients with histologically confirmed malignant mesothelioma was determined by laser now cytometry. Eight of the 19 tumors (42%) were diploid and 11 (58%) were aneuploid. Of the aneuploid tumors, only one showed multiploidy. The median survival time of the patients with diploid tumors was 19, 16, and 14 months from the onset of symptoms, diagnosis, and treatment, respectively. The median survival in patients with aneuploid tumors was 8, 7, and 7 months from the onset of first symptoms, diagnosis, and treatment. Thus, patients with diploid tumors lived longer than patients with aneuploid tumors. These results suggest that DNA ploidy analysis may be of prognostic value in malignant mesothelioma.

Original languageEnglish (US)
Pages (from-to)86-91
Number of pages6
JournalCytometry
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1995

Keywords

  • DNA content
  • Flow cytometry
  • Mesothelioma
  • Ploidy

ASJC Scopus subject areas

  • Hematology
  • Cell Biology
  • Pathology and Forensic Medicine
  • Biophysics
  • Endocrinology

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    Isobe, H., Sridhar, K. S., Doria, R., Cohen, F., Raub, W. A., Saldana, M., & Krishan, A. (1995). Prognostic significance of DNA aneuploidy in diffuse malignant mesothelioma. Cytometry, 19(1), 86-91. https://doi.org/10.1002/cyto.990190111