Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters.

S. M. Levy, R. B. Herberman, A. M. Maluish, B. Schlien, Marc E Lippman

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

Although findings from recent animal studies suggest that behavioral factors such as "helplessness" play a role in cancer progression, very few such studies with humans have been carried out. The study investigated the predictive power of an immunologic effector cell, the natural killer (NK) cell, as well as selected psychological and demographic factors, to breast cancer prognostic risk status. It was found that NK activity predicted the status of cancer spread to the axillary lymph nodes. Patients who had low levels of NK activity were rated as well-adjusted to their illness; patients who had higher NK activity appeared to be distressed or maladjusted. These findings are discussed in the light of recent animal findings linking environmental stress and behavioral responsiveness to biological vulnerability via endocrine and immune pathways.

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalHealth Psychology
Volume4
Issue number2
StatePublished - Jan 1 1985
Externally publishedYes

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Breast Neoplasms
Natural Killer Cells
Neoplasms
Lymph Nodes
Demography
Psychology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Levy, S. M., Herberman, R. B., Maluish, A. M., Schlien, B., & Lippman, M. E. (1985). Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychology, 4(2), 99-113.

Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. / Levy, S. M.; Herberman, R. B.; Maluish, A. M.; Schlien, B.; Lippman, Marc E.

In: Health Psychology, Vol. 4, No. 2, 01.01.1985, p. 99-113.

Research output: Contribution to journalArticle

Levy, SM, Herberman, RB, Maluish, AM, Schlien, B & Lippman, ME 1985, 'Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters.', Health Psychology, vol. 4, no. 2, pp. 99-113.
Levy SM, Herberman RB, Maluish AM, Schlien B, Lippman ME. Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. Health Psychology. 1985 Jan 1;4(2):99-113.
Levy, S. M. ; Herberman, R. B. ; Maluish, A. M. ; Schlien, B. ; Lippman, Marc E. / Prognostic risk assessment in primary breast cancer by behavioral and immunological parameters. In: Health Psychology. 1985 ; Vol. 4, No. 2. pp. 99-113.
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