Prognostic markers for bladder cancer

International Consensus Panel on bladder tumor markers

Tomonori Habuchi, Michael Marberger, Michael J. Droller, George P. Hemstreet, H. Barton Grossman, Jack A. Schalken, Bernd J. Schmitz-Dräger, William M. Murphy, Aldo V. Bono, Peter Goebell, Robert H. Getzenberg, Stefan H. Hautmann, Edward Messing, Yves Fradet, Vinata B. Lokeshwar

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The International Consensus Panel on cytology and bladder tumor markers evaluated markers that have the ability to predict tumor recurrence, progression, development of metastases, or response to therapy or patient survival. This article summarizes those findings. The panel mainly reviewed articles listed in PubMed on various prognostic indicators for bladder cancer. Based on these studies, most of which were case-control retrospective studies, various prognostic indicators were classified into 6 groups: (1) microsatellite-associated markers, (2) proto-oncogenes/oncogenes, (3) tumor suppressor genes, (4) cell cycle regulators, (5) angiogenesis-related factors, and (6) extracellular matrix adhesion molecules. The panel concluded that although certain markers, such as Ki-67 and p53, appear to be promising in predicting recurrence and progression of bladder cancer, the data are still heterogeneous. The panel recommends that identifying definitive criteria for test positivity, a clearly defined patient population, standardization of techniques used to evaluate markers, and clearly specified endpoints and statistical methods will help to bring accurate independent prognostic indicators into the clinical management of patients with bladder cancer.

Original languageEnglish
Pages (from-to)64-74
Number of pages11
JournalUrology
Volume66
Issue number6 SUPPL. 1
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

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Tumor Biomarkers
Urinary Bladder Neoplasms
Recurrence
Proto-Oncogenes
Angiogenesis Inducing Agents
Tumor Suppressor Genes
Oncogenes
PubMed
Microsatellite Repeats
Extracellular Matrix
Cell Biology
Case-Control Studies
Cell Cycle
Retrospective Studies
Neoplasm Metastasis
Survival
Population
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Habuchi, T., Marberger, M., Droller, M. J., Hemstreet, G. P., Grossman, H. B., Schalken, J. A., ... Lokeshwar, V. B. (2005). Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers. Urology, 66(6 SUPPL. 1), 64-74. https://doi.org/10.1016/j.urology.2005.08.065

Prognostic markers for bladder cancer : International Consensus Panel on bladder tumor markers. / Habuchi, Tomonori; Marberger, Michael; Droller, Michael J.; Hemstreet, George P.; Grossman, H. Barton; Schalken, Jack A.; Schmitz-Dräger, Bernd J.; Murphy, William M.; Bono, Aldo V.; Goebell, Peter; Getzenberg, Robert H.; Hautmann, Stefan H.; Messing, Edward; Fradet, Yves; Lokeshwar, Vinata B.

In: Urology, Vol. 66, No. 6 SUPPL. 1, 01.12.2005, p. 64-74.

Research output: Contribution to journalArticle

Habuchi, T, Marberger, M, Droller, MJ, Hemstreet, GP, Grossman, HB, Schalken, JA, Schmitz-Dräger, BJ, Murphy, WM, Bono, AV, Goebell, P, Getzenberg, RH, Hautmann, SH, Messing, E, Fradet, Y & Lokeshwar, VB 2005, 'Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers', Urology, vol. 66, no. 6 SUPPL. 1, pp. 64-74. https://doi.org/10.1016/j.urology.2005.08.065
Habuchi T, Marberger M, Droller MJ, Hemstreet GP, Grossman HB, Schalken JA et al. Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers. Urology. 2005 Dec 1;66(6 SUPPL. 1):64-74. https://doi.org/10.1016/j.urology.2005.08.065
Habuchi, Tomonori ; Marberger, Michael ; Droller, Michael J. ; Hemstreet, George P. ; Grossman, H. Barton ; Schalken, Jack A. ; Schmitz-Dräger, Bernd J. ; Murphy, William M. ; Bono, Aldo V. ; Goebell, Peter ; Getzenberg, Robert H. ; Hautmann, Stefan H. ; Messing, Edward ; Fradet, Yves ; Lokeshwar, Vinata B. / Prognostic markers for bladder cancer : International Consensus Panel on bladder tumor markers. In: Urology. 2005 ; Vol. 66, No. 6 SUPPL. 1. pp. 64-74.
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