Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience

S. M. Steinberg, Jamie S Barkin, R. S. Kaplan, D. M. Stablein

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location in 572 patients from the Gastrointestinal Tumor Study Group (GITSG), with resected Dukes' B2 and C colon cancer. Tumor location (left, right, and rectosigmoid/sigmoid) was of low prognostic importance (P>0.10), and did not effect survival or disease-free survival (P>0.10). Obstruction was an important indicator of prognosis, independent of Dukes' stage (P = 0.03) . Bowel perforation is associated with poor prognosis in disease-free survival (P = 0.001). Rectal bleeding had a positive impact on survival (P = 0.08). Thus, obstruction, perforation, and rectal bleeding (but not location) are found to be prognostic factors in patients with Dukes' B2 or C colon cancer.

Original languageEnglish
Pages (from-to)1866-1870
Number of pages5
JournalCancer
Volume57
Issue number9
StatePublished - Jan 1 1986

Fingerprint

Colon
Colonic Neoplasms
Disease-Free Survival
Neoplasms
Hemorrhage
Survival
Sigmoid Colon
Proportional Hazards Models
Breast

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Steinberg, S. M., Barkin, J. S., Kaplan, R. S., & Stablein, D. M. (1986). Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience. Cancer, 57(9), 1866-1870.

Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience. / Steinberg, S. M.; Barkin, Jamie S; Kaplan, R. S.; Stablein, D. M.

In: Cancer, Vol. 57, No. 9, 01.01.1986, p. 1866-1870.

Research output: Contribution to journalArticle

Steinberg, SM, Barkin, JS, Kaplan, RS & Stablein, DM 1986, 'Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience', Cancer, vol. 57, no. 9, pp. 1866-1870.
Steinberg, S. M. ; Barkin, Jamie S ; Kaplan, R. S. ; Stablein, D. M. / Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience. In: Cancer. 1986 ; Vol. 57, No. 9. pp. 1866-1870.
@article{a40eedbba8a2465cbec91f02b75e7735,
title = "Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience",
abstract = "This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location in 572 patients from the Gastrointestinal Tumor Study Group (GITSG), with resected Dukes' B2 and C colon cancer. Tumor location (left, right, and rectosigmoid/sigmoid) was of low prognostic importance (P>0.10), and did not effect survival or disease-free survival (P>0.10). Obstruction was an important indicator of prognosis, independent of Dukes' stage (P = 0.03) . Bowel perforation is associated with poor prognosis in disease-free survival (P = 0.001). Rectal bleeding had a positive impact on survival (P = 0.08). Thus, obstruction, perforation, and rectal bleeding (but not location) are found to be prognostic factors in patients with Dukes' B2 or C colon cancer.",
author = "Steinberg, {S. M.} and Barkin, {Jamie S} and Kaplan, {R. S.} and Stablein, {D. M.}",
year = "1986",
month = "1",
day = "1",
language = "English",
volume = "57",
pages = "1866--1870",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Prognostic indicators of colon tumors. The gastrointestinal tumor study group experience

AU - Steinberg, S. M.

AU - Barkin, Jamie S

AU - Kaplan, R. S.

AU - Stablein, D. M.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location in 572 patients from the Gastrointestinal Tumor Study Group (GITSG), with resected Dukes' B2 and C colon cancer. Tumor location (left, right, and rectosigmoid/sigmoid) was of low prognostic importance (P>0.10), and did not effect survival or disease-free survival (P>0.10). Obstruction was an important indicator of prognosis, independent of Dukes' stage (P = 0.03) . Bowel perforation is associated with poor prognosis in disease-free survival (P = 0.001). Rectal bleeding had a positive impact on survival (P = 0.08). Thus, obstruction, perforation, and rectal bleeding (but not location) are found to be prognostic factors in patients with Dukes' B2 or C colon cancer.

AB - This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location in 572 patients from the Gastrointestinal Tumor Study Group (GITSG), with resected Dukes' B2 and C colon cancer. Tumor location (left, right, and rectosigmoid/sigmoid) was of low prognostic importance (P>0.10), and did not effect survival or disease-free survival (P>0.10). Obstruction was an important indicator of prognosis, independent of Dukes' stage (P = 0.03) . Bowel perforation is associated with poor prognosis in disease-free survival (P = 0.001). Rectal bleeding had a positive impact on survival (P = 0.08). Thus, obstruction, perforation, and rectal bleeding (but not location) are found to be prognostic factors in patients with Dukes' B2 or C colon cancer.

UR - http://www.scopus.com/inward/record.url?scp=0022570096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022570096&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 1866

EP - 1870

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -