Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix

R. A. Potish, L. B. Twiggs, L. L. Adcock, K. A. Prem, J. E. Savage, B. S. Leung

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Tissue levels of cytosolic estrogen receptors (ER(c)) and progesterone receptors (PR(c)) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ER(c) and PR(c). To study the prognostic value of these receptors, 65 cervical carcinomas for ER(c) and PR(c) were assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ER(c) and PR(c) may prove to be useful prognostic factors in the management of cervical carcinomas.

Original languageEnglish
Pages (from-to)1709-1713
Number of pages5
JournalCancer
Volume58
Issue number8
StatePublished - Dec 10 1986
Externally publishedYes

Fingerprint

Progesterone Receptors
Uterine Cervical Neoplasms
Estrogen Receptors
Carcinoma
Spinal Manipulation
Endometrium
Cervix Uteri
Breast
Radiotherapy
Epithelium
Logistic Models
Survival
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Potish, R. A., Twiggs, L. B., Adcock, L. L., Prem, K. A., Savage, J. E., & Leung, B. S. (1986). Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. Cancer, 58(8), 1709-1713.

Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. / Potish, R. A.; Twiggs, L. B.; Adcock, L. L.; Prem, K. A.; Savage, J. E.; Leung, B. S.

In: Cancer, Vol. 58, No. 8, 10.12.1986, p. 1709-1713.

Research output: Contribution to journalArticle

Potish, RA, Twiggs, LB, Adcock, LL, Prem, KA, Savage, JE & Leung, BS 1986, 'Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix', Cancer, vol. 58, no. 8, pp. 1709-1713.
Potish RA, Twiggs LB, Adcock LL, Prem KA, Savage JE, Leung BS. Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. Cancer. 1986 Dec 10;58(8):1709-1713.
Potish, R. A. ; Twiggs, L. B. ; Adcock, L. L. ; Prem, K. A. ; Savage, J. E. ; Leung, B. S. / Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. In: Cancer. 1986 ; Vol. 58, No. 8. pp. 1709-1713.
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