Abstract
Tissue levels of cytosolic estrogen receptors (ER(c)) and progesterone receptors (PR(c)) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ER(c) and PR(c). To study the prognostic value of these receptors, 65 cervical carcinomas for ER(c) and PR(c) were assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ER(c) and PR(c) may prove to be useful prognostic factors in the management of cervical carcinomas.
| Original language | English |
|---|---|
| Pages (from-to) | 1709-1713 |
| Number of pages | 5 |
| Journal | Cancer |
| Volume | 58 |
| Issue number | 8 |
| State | Published - Dec 10 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix. / Potish, R. A.; Twiggs, L. B.; Adcock, L. L.; Prem, K. A.; Savage, J. E.; Leung, B. S.
In: Cancer, Vol. 58, No. 8, 10.12.1986, p. 1709-1713.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix
AU - Potish, R. A.
AU - Twiggs, L. B.
AU - Adcock, L. L.
AU - Prem, K. A.
AU - Savage, J. E.
AU - Leung, B. S.
PY - 1986/12/10
Y1 - 1986/12/10
N2 - Tissue levels of cytosolic estrogen receptors (ER(c)) and progesterone receptors (PR(c)) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ER(c) and PR(c). To study the prognostic value of these receptors, 65 cervical carcinomas for ER(c) and PR(c) were assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ER(c) and PR(c) may prove to be useful prognostic factors in the management of cervical carcinomas.
AB - Tissue levels of cytosolic estrogen receptors (ER(c)) and progesterone receptors (PR(c)) have been shown to have prognostic meaning in hormonally responsive cancers arising in the breast and endometrium. Although carcinomas of the uterine cervix rarely respond to hormonal manipulation, the normal cervical stroma and epithelia contain ER(c) and PR(c). To study the prognostic value of these receptors, 65 cervical carcinomas for ER(c) and PR(c) were assayed before initiation of surgical or radiation therapy. In premenopausal women, logistic models demonstrated that clinical stage, surgical stage, and receptor level independently predict survival. If confirmed in further studies, ER(c) and PR(c) may prove to be useful prognostic factors in the management of cervical carcinomas.
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M3 - Article
C2 - 3756793
AN - SCOPUS:0022539663
VL - 58
SP - 1709
EP - 1713
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 8
ER -